Drugs online research references
Zhongguo Yao Li Xue Bao. 1994 Jul;15(4):308-10.
Altered alpha 1-adrenoceptor density and alpha 1A/alpha 1B ratio in rat hearts after propranolol treatment.
Zhang Y, Hua Z, Wang XL.
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
After rats were treated with propranolol (50 mg.kg-1, bid, ip) for 7 d, the density of alpha 1-adrenoceptors in the rat myocardial cell membranes increased from 137 +/- 25 to 178 +/- 30 fmol/mg protein determined by receptor radioligand assay. Whereas the KD value was not significantly changed, the relative proportion of alpha 1A-adrenoceptor subtype increased from 19 +/- 6 to 31 +/- 8%. The affinities of two subtypes to 5-methylurapidil were not obviously changed after propranolol treatment. It was suggested that alpha 1A-subtype was more important in alpha 1-receptor mediated alterations after beta-adrenoceptor blockade.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7801769&dopt=Abstract
Am J Physiol. 1994 Dec;267(6 Pt 2):H2450-61.
Positive inotropic effect of Streptococcus faecalis in isolated cardiac muscle.
Schoemaker IE, Sys SU, Andries LJ, Meyers JM, Pattyn SR, Brutsaert DL.
Department of Physiology, University of Antwerp, Belgium.
Infective endocarditis is caused by bacterial colonization of the endocardium. Because endocardium modulates mechanical performance of subjacent myocardium, we studied acute effects of bacteria on isolated cardiac muscle and on the functional role of the endocardium. Bacteria, grown in broth at 37 degrees C, were added at increasing concentrations (10(2) to 10(6) bacteria/ml) to cat papillary muscles in Krebs-Ringer solution (1.25 mM Ca2+, 35 degrees C). The endocardial surface was damaged by exposing muscles to a stream of dry air for 30 s. Streptococcus (Enterococcus) faecalis induced significant increases in total peak isometric twitch tension (TT) and maximal velocity of unloaded shortening (Vmax) and significant decreases in time to TT (TtTT) and time to half isometric twitch tension decline (RT 1/2), both before and after removal of endocardial endothelium. This response could also be elicited with bacterial filtrate, after boiling the filtrate or after extracting the polysaccharides from it with KIO4. Increasing Ca2+ concentrations progressively reduced the response to the filtrate. Propranolol slightly, although not significantly, diminished the effects on TT and Vmax while abolishing the effects on TtTT and on RT 1/2. By contrast, Streptococcus bovis and Staphylococcus aureus did not affect TT or Vmax but induced a slight but significant decrease in TtTT at the highest concentration of bacteria. Accordingly, the filtrate of Strep. faecalis induces a positive inotropic effect. The active component is neither a protein nor a polysaccharide, and its effect may be partly beta-adrenoceptor mediated. Strep. bovis and Staph. aureus have negligible acute effects on contractility.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7810743&dopt=Abstract
Ann Cardiol Angeiol (Paris). 1994 Oct;43(8):452-7.
[Complete vagal block in the clinical evaluation of sinus bradycardia]
[Article in French]
Cina P, Kondili A, Ndrepepa G, Popa Y.
Qendra Spitalore Universitare, Sherbimi i Kardiologjise, Tirana, Albanie.
The authors determined the discriminant threshold of sinus rate (SR) and the degree of its increase after complete vagal block (0.04 mg/kg of atropine sulfate IV) in 34 patients with symptomatic sinus bradycardia, the day after electrophysiological evaluation (performed before and after autonomic block with propranolol 0.2 mg/kg and atropine sulfate 0.04 mg/kg IV). Patients were divided into two groups. Group I included 19 patients (age 43.3 +/- 8) with normal intrinsic sinus automatism with normal intrinsic heart rate (IHRo) and normal intrinsic corrected sinus recovery time (intrinsic CSRT) (< 425 ms). Group II consisted of 15 patients (age 51.8 +/- 12) with abnormal intrinsic sinus automatism with abnormal IHRo and/or intrinsic CSRT (> 425 ms). Following the atropine test, SR in the individuals of Group I increased from 58.1 +/- 11.7 bpm to 103 +/- 16 bpm (delta% = 80 +/- 37), while in Group II it increased from 52.8 +/- 12 bpm to 82.15 bpm (delta% = 55.4 +/- 21). The discriminant threshold of SR and of its percentage increase (delta%) were 91 bpm and 68% respectively, with a sensitivity of 71 and 81% and a specificity of 73 and 63%. The predictive value of a positive test of SR (< 91 bpm) and of its delta% (< 68%) were 71 and 64% respectively. That of a negative test of SR (> 91 bpm) and of its delta% (< 68%) were 73 and 80% respectively. The total predictive accuracy of SR and of its percentage increase was the same: 72%.(ABSTRACT TRUNCATED AT 250 WORDS)
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7825947&dopt=Abstract
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