Drugs online research references
Acta Radiol Diagn (Stockh). 1979;20(5):769-78.
Influence of contrast media osmolality on isolated rabbit heart performance.
Bongrani S, Baldi G, Cucchini F, di Donato M, Visioli O.
A low osmolality contrast medium (Iopamidol) caused less cardiac disturbance on isolated rabbit heart than a high osmolality medium (Urografin). The same effects were induced by glucose solutions iso-osmolal with the two media. After perfusion with Propranolol (1 microgram/ml) and Cimetidine (1 microgram/ml) the observed effect was unaltered.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=93401&dopt=Abstract
J Invest Dermatol. 1995 May;104(5):835-8.
Involvement of phospholipase D in ganglioside GQ1b-induced biphasic diacylglycerol production in human keratinocytes.
Seishima M, Aoyama Y, Mori S, Nozawa Y.
Department of Dermatology, Gifu University School of Medicine, Japan.
Ganglioside IV3 (NeuAc)2, II3 (NeuAc)2-GgOse4Cer (GQ1b), which induces terminal differentiation in keratinocytes, was previously found to enhance the mass content of inositol 1,4,5-trisphosphate and intracellular calcium concentration ([Ca++]i), peaking at 30 seconds. In the present study, the biphasic accumulation of 1,2 diacylglycerol, i.e., the first transient and the second sustained phase, was observed in cultured human keratinocytes stimulated by GQ1b. On the other hand, II3 NeuAc-LacCer (GM3), which inhibits keratinocyte proliferation without inducing differentiation, did not cause diacylglycerol formation. Phosphatidylethanol, produced by transphosphatidylation and a potential marker for phospholipase D activity, was produced by the exposure to GQ1b in the presence of ethanol. The second sustained phase of diacylglycerol was repressed by ethanol, indicating that the diacylglycerol-formation pathway via phospholipase D followed by phosphatidic acid phosphohydrolase would in part account for the second diacylglycerol phase. Furthermore, this second phase of GQ1b-induced diacylglycerol generation was reduced by pretreatment with propranolol, an inhibitor of phosphatidic acid phosphohydrolase. In addition, the levels of [3H]choline, a direct metabolite of the phospholipase D pathway, were elevated within 1 min after GQ1b addition and then sustained for at least 20 min. Taken together, the results suggest that the phospholipase D pathway may contribute to the second phase of diacylglycerol formation, which might be involved in differentiation.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7738364&dopt=Abstract
Am J Respir Cell Mol Biol. 1995 May;12(5):531-9.
Receptor-specific functional properties of beta 2-adrenergic receptor autoantibodies in asthma.
Turki J, Liggett SB.
Department of Medicine (Pulmonary), University of Cincinnati College of Medicine, Ohio, USA.
beta 2-Adrenergic receptor (beta 2 AR) autoantibodies have been reported in the serum from subjects with asthma but the functional significance of such antibodies is not known. To characterize these antibodies, we developed a Western blot (WB) technique that utilized overexpressed recombinant human beta 2AR as antigen and also developed a control antisera in rabbits directed against the C-terminus of the receptor. beta 2AR autoantibodies were detected in approximately 5% of normal subjects and in approximately 40% of asthmatic subjects. Eighty-four percent of these antibodies were of the IgG class, with the remainder being IgM. Most (73%) of WB-positive sera inhibited [125I]cyanopindolol binding to recombinant solubilized receptors. The mean binding inhibition was 40.4 +/- 5.1% for WB-positive sera versus 7.6 +/- 1.2% for WB-negative sera. Binding of antibody to beta 2AR expressed on intact cells significantly depressed receptor function, with a > 50% attenuation of isoproterenol-stimulated cAMP production. This effect was receptor specific, as forskolin-stimulated cAMP accumulation was not affected by exposure to sera. WB-positive sera that did not inhibit radioligand binding had no effect on receptor function. Thus, some antibodies appear to bind near the ligand binding pocket and act as functional antagonists. In addition, incubation of intact cells expressing beta 2AR with WB-positive sera for 18 h resulted in a 30.3 +/- 0.6% downregulation of receptor number, whereas WB-negative sera induced no downregulation. This downregulation response with WB-positive sera was not affected by coincubation with the antagonist propranolol and was apparently not dependent upon whether the antibody interacted with ligand binding pocket.(ABSTRACT TRUNCATED AT 250 WORDS)
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7742016&dopt=Abstract
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