Drugs online research references
Psychopharmacology (Berl). 1995 Mar;118(1):10-8.
Pharmacologic specificity of antidepressive activity by monoaminergic neural transplants.
Dougherty DD, Sortwell CE, Sagen J.
Department of Anatomy and Cell Biology, University of Illinois at Chicago 60612, USA.
Previous studies in our laboratory have demonstrated the ability of monoaminergic transplants in the rat frontal cortex to produce antidepressive activity in both the learned helplessness model and the forced swimming test, as well as to increase monoamine levels in the implanted frontal cortex. These findings implicate increased cortical levels of norepinephrine (NE) and serotonin (5-HT) in the antidepressive activity of monoaminergic transplants. The goal of the present study was to characterize the pharmacologic mechanisms involved in the monoaminergic graft-induced antidepressive activity. Immobility scores in the forced swimming test (FST) were assessed after transplantation of 5-HT-containing pineal gland tissue, NE-containing adrenal medullary tissue, a combination of both tissues, or sciatic nerve (control) into the rat frontal cortex and compared to non-transplanted and chronic imipramine-treated rats. Monoaminergic transplants and imipramine treatment significantly reduced immobility scores in the FST in contrast to control transplanted or untreated animals. All groups were assessed pharmacologically with the adrenergic antagonists phentolamine (alpha) and propranolol (beta), and serotonergic antagonists metergoline (5-HT1/5-HT2) and pirenperone (5-HT2). Serotonergic antagonists, particularly the 5HT2 antagonist, blocked the reduction in FST immobility induced by the pineal implants. Adrenergic antagonists not only blocked FST immobility reductions in adrenal medullary grafted animals, but over-compensated for the adrenal transplants, producing a large increase in immobility. The FST reduction induced by pineal and adrenal cografts was blocked by all four monoaminergic antagonists. FST immobility scores in control transplanted and non-transplanted animals were not altered by any of the antagonists. The immobility reduction produced by chronic imipramine treatment was blocked significantly only by propranolol.(ABSTRACT TRUNCATED AT 250 WORDS)
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7597115&dopt=Abstract
Biol Pharm Bull. 1997 Apr;20(4):421-7.
Relationship between amount of beta-blockers permeating through the stratum corneum and skin irritation after application of beta-blocker adhesive patches to guinea pig skin.
Kobayashi I, Hosaka K, Ueno T, Maruo H, Kamiyama M, Konno C, Gemba M.
Toxicological Research Center, Nitto Denko Corporation, Osaka, Japan.
We evaluated the relationship between the cumulative amounts of 5 kinds of beta-blockers (alprenolol, oxprenolol, timolol, acebutolol and atenolol) permeating through the stratum corneum and a* values obtained by measuring the formation of erythema, a skin irritation reaction, with a chromameter after transdermal application of adhesive patches containing 2 beta-blocker to the skin of guinea pigs. The cumulative amount of beta-blocker released from each adhesive patch to the skin increased with the increase in application time. The contents of alprenolol, oxprenolol and timolol in the stratum corneum and in the stripped skin increased markedly up to 4 h after application and thereafter were maintained at high levels up to 24 h. The contents of acebutolol and atenolol, on the other hand, increased up to 24 h, but these values were low. a* values of all adhesive patches 24 h after application were higher than those before application. The correlation coefficients between the cumulative amounts of alprenolol, oxprenolol, timolol, acebutolol or atenolol permeating through the stratum corneum and (delta a* -delta a*Placebo) values were 0.739, 0.717, 0.722, 0.551 and 0.633, respectively. The correlation coefficient calculated by averaging the cumulative amounts of 6 kinds of beta-blockers permeating through the stratum corneum [including propranolol which was reported previously (Kobayashi I., et al., Biol. Pharm. Bull., 19, 839-844 (1996))] was 0.731, higher than the correlation coefficient between contents of these beta-blockers in the stripped skin and (delta a* -delta a*Placebo) values (r = 0.552). This suggests that there was a high correlation between the cumulative amounts of beta-blockers permeating through the stratum corneum and (delta a* -delta a*Placebo) values.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9145222&dopt=Abstract
Clin Exp Allergy. 1995 Apr;25(4):304-11.
Regulation of IgE production from human mononuclear cells by beta 2-adrenoceptor agonists.
Coqueret O, Dugas B, Mencia-Huerta JM, Braquet P.
Institut Henri Beaufour, Immunology Department, Les Ulis, France.
The present study examined the effect of beta 2-adrenoceptor agonists on the interleukin-4 (IL-4)-driven IgE production and on the possible mechanisms of action of these compounds. We present evidence that salbutamol and fenoterol potentiated the IL-4-induced IgE production by human peripheral blood mononuclear cells (PBMC). No significant effect of incubation in the presence of beta 2-adrenoceptor agonists on IgG, IgA and IgM production was observed. Salbutamol and fenoterol inhibited interferon-(IFN)-gamma production by PHA-activated human PBMC suggesting that the blockade of the production of this cytokine could possibly explain the enhancement of IgE production. Salbutamol and fenoterol potentiated the IL-4-induced production of sCD23 whereas no effect on CD23 expression was observed. The potentiating effect of salbutamol on IgE production was blocked by two antagonists of beta 2-adrenoceptor, namely butoxamine and D,L-propranolol, suggesting a beta-adrenoceptor-mediated event. These results demonstrate that beta 2-adrenoceptor stimulation results in an increase in IgE production by human B lymphocytes.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7600375&dopt=Abstract
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