Drugs online research references
Eksp Klin Farmakol. 1995 Jul-Aug;58(4):29-32.
[The effect of damage to the hypothalamic suprachiasmatic nuclei in rats on the restructuring of the dynamic indices of the cardiointervalogram induced by propranolol]
[Article in Russian]
Arushanian EB, Beier EV, Popov AV.
Daily variations in the heart rate were studied. Chronic treatment with propranolol attenuated the sympathetic tone only at night and promoted acrophase in the morning. The complete lesion of suprachiasmatic nuclei balanced the circadian rhythm of the heart rate variability and the effect of drug.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7580748&dopt=Abstract
Rom J Physiol. 1993 Jul-Dec;30(3-4):241-7.
Endogenous opioid abstinence syndrome.
Cristea A, Restian A, Vaduva G.
Postgraduate Medical Training Center, Bucharest, Romania.
Starting from the observation that an increase of stress analgesia is followed by a hyperalgesia period, with a series of symptoms characteristic of the exogenous opioid abstinence syndrome (EXOAS), the authors supposed also the possibility of the existence of an endogenous abstinence syndrome (ENOAS). In order to demonstrate the existence of this syndrome, they investigated at first the possibility of the appearance of an acute tolerance to opioids. Then they followed-up the course of behaviour during and after informational stress in untreated animals, in animals treated with naloxone, which--being an antagonist of opioids--can induce EXOAS in toxicomaniacs, and in animals treated with clonidine and propranolol, that are used in the treatment of EXOAS. Experimental researches have demonstrated the possibility of ENOAS occurrence, its aggravation by naloxone and its improvement with clonidine and propranolol.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7582938&dopt=Abstract
Fertil Steril. 1995 Dec;64(6):1113-9.
Growth hormone, insulin-like growth factor-I axis, and insulin secretion in hyperandrogenic adolescents.
Ibanez L, Potau N, Georgopoulos N, Prat N, Gussinye M, Carrascosa A.
Adolescent and Endocrine Unit, Hospital Universitario Materno-Infantil Vall d'Hebron, Barcelona, Spain.
OBJECTIVE: To assess GH and insulin-like growth factor I (IGF-I) axis variability in hyperandrogenic adolescents with different sources of androgen excess and their relationship with insulin resistance. DESIGN: Baseline IGF-I, insulin-like growth factor binding protein-1 (IGFBP-1), IGFBP-3, GH response to the exercise-propranolol test, and insulin responses to a standard oral glucose tolerance test were compared among patients with functional ovarian hyperandrogenism, hyperandrogenic nonfunctional ovarian hyperandrogenism patients, and age-matched controls. SETTING: Outpatient clinic in a medical center. PATIENTS: Twenty-one adolescents with ovarian (group A) and 17 with nonovarian (group B) hyperandrogenism, and 20 controls. RESULTS: Serum IGF-I and poststimulated GH levels were similar among groups, whereas serum IGFBP-3 levels were significantly lower in group A than in controls. Mean serum insulin levels were significantly higher in patients than in controls, whereas 24% of patients had abnormal insulin responses to glucose and/or insulin sensitivity indexes. Serum IGFBP-3 levels correlated negatively with the free androgen index (free androgen index = T/sex hormone-binding globulin [SHBG] x 100), whereas mean serum insulin levels correlated positively with the free androgen index and negatively with SHBG levels in all subjects. CONCLUSIONS: Hyperinsulinemia is common in hyperandrogenic adolescents and correlates with the degree of hyperandrogenism and not with the androgen source. Hyperinsulinemia and decreased IGFBP-3 levels may enhance IGF-I bioavailability, which in turn may both decrease SHBG levels and increase androgen production.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7589662&dopt=Abstract
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