Drugs online research references
Dis Colon Rectum. 1981 Jan-Feb;24(1):5-16.
Angiography with epinephrine and beta receptor blocker in diagnosis of sigmoid lesions.
Holmstrom B, Uden R.
Various sigmoid lesions, seen on barium enema of 39 patients, were investigated with angiography of the inferior mesenteric artery using three series. The first was performed with contrast medium only, the second after use of epinephrine, and the third after a beta-blocking agent (propranolol) combined with epinephrine. The patients were followed for more than three years. Eleven carcinomas were detected, all diagnosed angiographically. Carcinoma, radiation fibrosis, and diverticulitis with fibrosis may appear similar on pharmacoangiography, but the inflammatory reaction seen, for example in diverticulitis, is different. These findings are important because they can have an influence on the indications and selection of the most suitable operation to be performed.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7472104&dopt=Abstract
Acta Anaesthesiol Scand. 1995 Aug;39(6):802-8.
Spinal anesthesia attenuates myocardial ischemia during coronary artery spasm induced by intraaortic methacholine in rats.
Mizuyama K, Sato S, Okubo N, Naito H.
Department of Anesthesiology, University of Tsukuba, Japan.
Coronary artery spasm is not rare in patients with coronary artery disease, but the influence of regional anesthesia on spasm-induced myocardial ischemia is not known. We investigated the effects of spinal anesthesia on myocardial ischemia during coronary artery spasm in rats, and compared these with the effects of an alpha- and beta-adrenergic antagonist, and an alpha-adrenergic agonist. An intraaortic catheter was inserted via the right internal carotid artery so that the tip of the catheter was placed near the coronary ostium. An intrathecal catheter was placed at lumbar level. Coronary spasm was induced by the intraaortic injection of methacholine, and we identified the thresholds of myocardial ischemia, defined as the dose of methacholine that induced ST-segment elevation. Subsequently, the thresholds were determined after spinal anesthesia, and after the intraaortic injection of phentolamine and propranolol. The thresholds of myocardial ischemia increased significantly after intrathecal bupivacaine. In contrast, the threshold did not change after the injection of phentolamine. The thresholds increased significantly after the injection of propranolol. Methoxamine significantly decreased the threshold of ischemia. These results demonstrated that spinal anesthesia attenuated myocardial ischemia during methacholine-induced coronary spasm. This effect was equivalent to that of propranolol.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7484038&dopt=Abstract
Arzneimittelforschung. 1995 Sep;45(9):1032-5.
[The effect of noradrenaline and dopamine agonists and antagonists on oxygen consumption in some insect and crustacean species]
[Article in German]
Weischer ML, Hano R.
Institut fur Pharmakologie und Toxikologie, Westfalischen Wilhelms-Universitat Munster.
The effect of drugs on oxygen consumption in some invertebrate species (insect larvae and crustacea) was investigated. Insect larvae showed an increase in oxygen consumption under the influence of sympathomimetic drugs such as isoprenaline or orciprenaline which could be prevented by beta-receptor antagonists like propranolol or butoxamine. The drugs had no effect in crustacea. On the other hand, in these animals dopamine agonists of different chemical structure (amphetamine, apomorphine, lisuride) caused an increase in oxygen consumption whereas the dopamine antagonist metoclopramide had an opposite effect.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7488307&dopt=Abstract
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