Drugs online research references
Ann Endocrinol (Paris). 1980 Mar-Apr;41(2):127-31.
[Evaluation of the potential cardiotoxicity of propranolol-lithium gluconate association (author's transl)]
[Article in French]
Descotes J, Lievre M, Ollagnier M, Faucon G, Berthezene F, Evreux JC.
The association B blocking agent-lithium salt is used for the therapy of some severe hyperthyroidism with cardiotoxicosis. Separately, both drugs depress intracardiac conduction. However by recording the potentials of the His bundle in anesthetized dogs, a potential cardiotoxicity of this association is unlikely since sinusal automaticity alone is importantly slowed. But, these results need further confirmation in man.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7469381&dopt=Abstract
Artery. 1980;7(3):232-45.
Serotonin receptors subserve only contraction in canine and rat pulmonary arteries and veins.
Chand N, Altura BM.
Precise information with respect to whether serotonin (5-HT) exerts direct effects on mammalian pulmonary arteries and veins is lacking. The present studies, using isolated pulmonary arterial strips of dogs and rats, as well as isolated pulmonary veins of dogs, indicate that serotonin exerts direct contractile, but not relaxant, effects on these blood vessels. Contractile responses to 5-HT were not influenced by "specific" receptor-blocking doses of pyrilamine (H1-receptor antagonist), metiamide (H2-receptor antagonist), phentolamine (alpha-adrenoceptor antagonist), propranolol (beta-receptor antagonist), atropine (cholinergic antagonist) or morphine ("M" tryptamine antagonist). These data demonstrate the lack of interaction of 5-HT with either H1- and H2-histamine, alpha and beta-adrenergic, cholinergic, or "M" tryptamine receptors in these pulmonary blood vessels. Selective, competitive antagonism of 5-HT-induced contractions by methysergide (parallel shifts of concentration-effect curves) demonstrate a direct action of 5-HT on D-type serotonin receptors in these pulmonary blood vessels.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7469796&dopt=Abstract
Br J Pharmacol. 1980;71(1):35-40.
Pharmacological study of the anococcygeus muscle of the dog.
Dehpour AR, Khoyi MA, Koutcheki H, Zarrindast MR.
1 The response of the dog anococcygeus muscle to field stimulation and to some drugs has been studied. The results are compared with those reported previously in the rat, cat and rabbit. 2 Field stimulation produced frequency-dependent contractions which were inhibited by guanethidine and phentolamine. When the tonus of the muscle was increased with guanethidine, field stimulation always produced frequency-dependent relaxation. The relaxation was not prevented by propranolol. 3 The muscle was contracted by noradrenaline, tyramine, acetylcholine, histamine (H1), 5-hydroxy-tryptamine, prostaglandin E2 and vasopressin. Phentolamine, atropine, promethazine (but not cimetidine) and methysergide inhibited the effect of the respective agonists. 4 After increasing the tonus of the muscle, it was relaxed by low concentrations of isoprenaline. The relaxation was antagonized by propranolol. 5 The response to adenosine triphosphate (ATP) was variable. In some preparations, it relaxed the muscle, in others it contracted the muscle prior to relaxation, in others still it only contracted the muscle. Indomethacin did not prevent ATP-induced contraction. 6 It is concluded that the anococcygeus of the dog, like that of rat, cat and rabbit, has an adrenergic motor innervation and an inhibitory innervation, the transmitter of which is not identified.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7470746&dopt=Abstract
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