Drugs online research references
Kardiologiia. 1980 Oct;20(10):19-24.
[Use of obzidan in the acute period of myocardial infarct]
[Article in Russian]
Gvatua NA, Kravtsov VL, Ivanova LK, Shkliar LV, Shumakov VA.
Forty-four patients with acute myocardial infarction were given 0.15 mg/kg propranolol (obsidan) by intravenous drip, after which 80--160 mg of the drug were given daily by mouth for 4--5 days. The extent of the ischemic damage and the dynamics of the infarction zone were judged according to the results of electrocardiotopogram recorded from 35 leads and serial tests for creatine phosphokinase activity in blood serum. The hemodynamic shifts occurring under the effect of the treatment were determined in the same patients. The results were compared with those in a control group (37 patients) identical in clinical and hemodynamic signs. It is established that obsidan given by the schedule proposed reduces significantly the electrocardiographic signs of ischemic damage to the myocardium (according to the ST segment) and the spread of the zone of necrosis in the first days of the follow-up. This is attended by deceleration of the cardiac rhythm and a decrease in systemic arterial pressure and cardiac output. The hemodynamic shifts occur within the ranges of admissible fluctuations and do not cause circulatory insufficiency as a rule.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7441957&dopt=Abstract
Res Commun Chem Pathol Pharmacol. 1980 Nov;30(2):329-39.
Factors affecting the plasma protein binding of verapamil and norverapamil in man.
Yong CL, Kunka RL, Bates TR.
The in vitro and vivo binding of the antiarrhythmic agent verapamil and its active metabolite norverapamil to human plasma proteins was determined under different conditions at 37 degrees C by equilibrium dialysis. The binding of verapamil was considerable (free fraction of about 0.10) and was independent of plasma concentration over the range of 50 ng/ml to 1500 ng/ml. Norverapamil was also extensively bound to plasma proteins. Verapamil binding was reduced significantly upon plasma dilution and upon addition of three of its major metabolites (norverapamil and metabolites A and B). Therapeutic concentrations of several drugs including disopyramide (12 micrograms/ml), diazepam (2 micrograms/ml), lidocaine (4 micrograms/ml), propranolol (150 ng/ml), and salicylate (250 microgram/ml) also significantly increased the free fraction of verapamil. The results of in vivo protein binding studies using plasma samples collected during a steady-state dosing interval from a patient receiving 80 mg of verapamil orally every 6 hr were similar to those obtained from vitro binding studies.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7444161&dopt=Abstract
S Afr Med J. 1980 Dec 13;58(24):978-80.
Sympathetic hyperreflexia in tetraplegics. The value of systolic time intervals in assessing drug effects.
Sommers DK.
The arterial blood pressure, heart rate and systolic time intervals were measured in 10 male tetraplegic subjects before and during the filling of the bladder with sterile normal saline. This procedure was repeated on separate occasions after pretreatment of the patients with blocking dosages of propranolol, labetalol, phenoxybenzamine and guanethidine respectively. During hyperreflexia the pre-ejection period/left ventricular ejection time (PEP/LVET) ratio and the PEP and electromechanical systole (QS2) reduced, suggesting positive inotropic effects. Propranolol practically eliminated these effects and labetalol also opposed them. The effects of phenoxybenzamine and guanethidine were unpredictable.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7444702&dopt=Abstract
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