Drugs online research references
Jpn Heart J. 1980 Sep;21(5):753-9.
Effect of N-(4-butoxybenzyl) hyoscyaminium bromide (butropium bromide) on the isolated, blood-perfused canine atrium preparation.
Chiba S.
The effects of butropium on chronotropic and inotropic activity were investigated in 10 isolated atrial preparations which were suspended in a bath and perfused with arterial blood led from a carotid artery of heparinized support dog. Butropium injected into the cannulated sinus node artery in a dose range of 3 to 100 microgram produced a dose-dependent positive chronotropic and inotropic effect. At relatively higher doses above 30 microgram, slight and brief initial negative chronotropic and inotropic effect followed by a long-lasting positive effect was observed. The positive effect of butropium was markedly suppressed by propranolol or carteolol, but it was not affected by tetrodotoxin or desmethylimipramine. From these results, a large amount of butropium may induce positive chronotropic and inotropic effect through cholinergic blockade and in part stimulation of adrenergic beta-receptors.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7431672&dopt=Abstract
Respiration. 1980;40(1):38-46.
Pulmonary gas exchange after propranolol in patients with ischaemic heart disease.
Jebavy P, Ressl J, Jandova R.
Pulmonary gas exchange was evaluated after 10 mg i.v. propranolol in 12 patients 3-6 months after acute myocardial infarction undergoing haemodynamic examination in our outpatient department. None of them exhibited clinical signs of heart failure or obstructive airways disease. Routine spirometric examination was normal in all patients. Propranolol led to a distinct deterioration of LV function and to a fall in left ventricular filling pressure both at rest and during exercise. At rest, the administration of propranolol resulted only in a significant decrease of total ventilation. During exercise, its administration was followed by a significant decrease of the tidal volume, alveolar ventilation and VA/VE index. Arterial CO2 tension and physiological dead space ventilation increased significantly. Arterial oxygen tension decreased after propranolol insignificantly both at rest and during exercise. No patient reported dyspnoea after propranolol; 8 patients reported a decrease or disappearance of effort dyspnoea. None exhibited clinical signs of bronchospasm.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7433774&dopt=Abstract
Curr Med Res Opin. 1980;7(2):91-5.
Effect of propranolol on the lower oesophageal sphincter in man.
Thorpe JA.
The effect of an intravenous dose (2 mg) of propranolol in the lower oesophageal sphincter was studied in 10 human volunteers. A hydraulic-capillary infusion manometric technique was used to measure the lower oesophageal sphincter pressure. A significant increase in sphincter pressure was recorded, together with increased amplitude and duration of oesophageal peristaltic activity. This study confirms the presence of specific beta-receptors in the lower oesophageal sphincter.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7438773&dopt=Abstract
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