Drugs online research references
Eur J Clin Pharmacol. 1980 Aug;18(2):135-9.
Comparison of the effects of propranolol and labetalol on renal haemodynamics at rest and during exercise in essential hypertension.
Larsen JS, Pedersen EB.
The effect of exercise on renal haemodynamics was examined in young patients with mild essential hypertension. Four groups of subjects were studied: 13 normotensive, healthy control subjects, and 15 untreated, 11 propranolol-treated, and 6 labetalol-treated patients. Renal plasma flow (RPF) and glomerular filtration rate (GFR) were measured during four consecutive periods, a pre-exercise control period, two exercise periods with loads of 450 kpm/min and 600 kpm/min, respectively, and a post-exercise control period. In the untreated patients RPF and GFR were lower during exercise than in the normotensive control subjects, whereas no significant differences were found at rest. In the propranolol-treated patients the reduction in RPF and GFR during exercise was more pronounced than in the untreated hypertensives. In the labetalol-treated patients however, RPF and GFR were reduced only to the same degree as in the untreated hypertensives. The reduced renal blood flow in propranolol-treated patients may be attributed to a compensatory increase in sympathetic activity caused by an impaired cardiac response to exercise. The lack of reduction in renal blood flow during labetalol therapy could partly be related to alpha-adrenergic blockade in the renal vascular bed induced by labetalol, and partly to the smaller reduction in cardiac output during labetalol than during propranolol therapy.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7428793&dopt=Abstract
Eur J Clin Pharmacol. 1980 Aug;18(2):141-6.
Influence of propranolol and pindolol on the haemodynamic effects of papaverine, isoprenaline and noradrenaline in hypertensive patients.
Chu D, Cocco G, Schweda E, Haeusler G, Strozzi C.
The influence of two beta-adrenoceptor antagonists, propranolol and pindolol, on the haemodynamic effects of papaverine, isoprenaline and noradrenaline was investigated in 9 male patients with first degree essential hypertension. Propranolol and pindolol were given according to a doubleblind, crossover scheme. Heart rate and blood pressure were measured before and after each treatment. Propranolol 670 microgram/kg i.v. reduced the supine and standing systolic blood pressures by 2.3% and 1.6%, respectively. Similarly, the intravenous administration of pindolol 35 microgram/kg reduced supine and standing systolic blood pressure by 5.5% and 8.3% respectively (clinically insignificant). Neither drug affected diastolic blood pressure. Following propranolol, there were moderate reduction in supine and standing heart rates, respectively by 24% and 20% (p < 0.001). Similarly, but to a lesser extent, pindolol reduced supine and standing heart rate by 12% and 17% (p < 0.001). The effects of papaverine, which, at 1.5 mg/kg i.v. reduced systolic blood pressure by 5-10% and increased heart rate by 8-15%, were not significantly influenced by the beta-blockers. The blood pressure and heart rate responses to isoprenaline, on the other hand, were attenuated or inhibited by both beta-blockers. While the beta-blockers inhibited the beta-adrenoceptor component of noradrenaline, the pressor component of noradrenaline, which is mediated through the alpha-adrenoceptors, was not influenced by propranolol, but was inhibited after pindolol. It is concluded that pindolol differs qualitatively from propranolol in that it inhibited both the alpha and beta-adrenoceptor effects of noradrenaline.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7428794&dopt=Abstract
J Endocrinol. 1980 Oct;87(1):73-80.
Comparison of the regulation of calcitonin in serum of old and young Buffalo rats.
Queener SF, Bell NH, Larson SM, Henry DP, Slatopolsky E.
Studies were carried out to characterize the secretion and the effects of calcitonin in the Buffalo rat. Mean basal concentrations of calcitonin and parathyroid hormone were significantly increased in serum of rats older than 6 months of age as compared with rats between 2 and 3 months of age. The mean concentration of calcium in serum was independent of age. In both age groups, serum calcitonin was increased by administration of calcium (1 mmol/kg body wt) or isoproterenol (100 microgram/kg body wt), was diminished by beta-adrenergic blockade with DL-propranolol (1 mg/kg body wt) and was not altered by either pentagastrin or glucagon (200 and 100 microgram/kg body wt respectively). The average weight of the thyroid glands was significantly greater in the old than in the young animals but the mean concentration of calcitonin in the thyroids was the same. Thyroparathyroidectomy produced a transient increase followed by a fall in mean serum calcium in the old rats. In contrast, a progressive decline in the mean concentration of calcium in serum was observed after thyroparathyroidectomy in the young rats. Treatment of old animals with reserpine (2.5 mg/kg body wt) markedly depleted noradrenaline in the thyroid, lowered calcitonin in serum and converted the pattern of response of serum calcium to thyroparathyroidectomy to that observed in young animals. The results provide evidence that hypercalcitonaemia occurs in aged Buffalo rats, as does hyperparathyroidism, and that the concentrations of calcitonin in blood are modulated by beta-adrenergic affectors. Glucagon and pentagastrin exhibit little if any effects on calcitonin secretion in this strain of rat regardless of age.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7430917&dopt=Abstract
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