Drugs online research references
J Pharm Sci. 1980 Oct;69(10):1191-3.
Determination of pindolol in biological fluids by electron-capture GLC.
Guerret M, Lavene D, Kiechel JR.
An electron-capture GLC method was developed for measuring pindolol in human plasma and urine. The unchanged drug was extracted with benzene from alkalinized plasma or urine using propranolol as the internal standard. Both compounds subsequently were back-extracted into 0.1 M HCl and then into benzene. After evaporation of the organic phase, the compounds were derivatized with trifluoroacetylimidazole to form the trifluoroacetyl ester of pindolol and propranolol. These derivatives then were analyzed by electron-capture GLC. The method allowed the measurement of concentrations as low as 1 ng of pindolol/ml of plasma and was applied successfully to determinations of plasma levels in humans after oral administraton of a single 10-mg dose of pindolol.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7420290&dopt=Abstract
Acta Biol Med Ger. 1978;37(5-6):801-5.
Influence of prostaglandins, prostaglandin-precursors and of a linoleic acid rich and free diet on the cardiac effects of isoprenaline and vasodilators.
Mentz P, Hoffmann P, Lenken V, Forster W.
In isolated auricle preparations of guinea pigs arachidonic acid diminished the increase in cardiac performance by isoprenaline in a similar way as PGE1 and propranolol. Long term pretreatment of rats with a linoleic acid (LA) supplemented diet increased in vivo the maximal systolic pressure and decreased the heart rate. In hearts in vitro the LA rich diet decreased the heart rate, increased the coronary flow and showed a tendency to enhance the contraction force. The release of cardiac prostaglandin-like substances was increased. Simultaneously the LA rich diet reduced the heart rate increase and the positive inotropic effect of isoprenaline without changing the increase in the coronary flow and without any effect on the heart performance of coronary vasodilators like oxyfedrine and prenylamine.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=742291&dopt=Abstract
Am J Physiol. 1980 Oct;239(4):E255-E264.
Parathyroid hormone response to dopamine in cattle.
Blum JW, Kunz P, Fischer JA, Binswanger U, Lichtensteiger W, Da Prada M.
The effects of dopaminergic agonists on plasma levels of parathyroid hormone (PTH) have been studied in cattle. PTH increased within minutes in a dose-dependent manner during intravenous infusions of dopamine (DA) or epinine. Bromocriptine, in amounts that lowered plasma prolactin, inconsistently elevated PTH. Pimozide suppressed PTH responses to DA, whereas propranolol, phentolamine, phenylephrine, and atropine were ineffective. Plasma calcium and magnesium remained unaltered during DA and epinine infusions. Therefore DA appears to stimulate PTH secretion directly. After prolonged DA infusions, the secretion of PTH became resistant to both the administration of DA and isoproterenol, whereas the parathyroid glands remained responsive to a hypocalcemia. On the other hand, calcium suppressed PTH responses to DA. The results suggest that DA, beta-adrenergic agonists, and low calcium stimulate PTH secretion by separate but closely related mechanisms. Based on biochemical and histochemical observations on DA occurring in high amounts in bovine parathyroid glands, it is conceivable that this amine might stimulate PTH secretion at the level of the gland.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7425119&dopt=Abstract
Herbs and Pharmaceuticals Online ||
Hair Million herbal formula for hair loss and hair growth ||
Wellstreet online pharmacy for click-order prescription medications ||
Altace Online Pharmacy ||
Rx Drugs USA, Prescription Drugs Online Pharmacy ||
Insurance plans and information ||
Insurance policies for all purposes ||
Antibiotics and prescription medications online literature ||