Drugs online research references
J Chromatogr. 1980 Aug 8;183(2):213-20.
Determination of propranolol and its major metabolites in plasma and urine by high-performance liquid chromatography without solvent extraction.
Lo M, Riegelman S.
Fast, reliable, specific and sensitive methods are reported to accurately quantitate unchanged, propranolol in plasma, and its major metabolites in plasma and urine after enzymatic hydrolysis without the need for solvent extraction. These methods enable the analyst to process a large number of propranolol samples in one working day and should prove valuable to clinical laboratories demanding both speed and specificity in an assay.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7400279&dopt=Abstract
Naunyn Schmiedebergs Arch Pharmacol. 1980 Jul;312(3):265-70.
Sauvagine, a new polypeptide from Phyllomedusa sauvagei skin. Occurrence in various Phyllomedusa species and pharmacological actions on rat blood pressure and diuresis.
Erspamer V, Erspamer GF, Improta G, Negri L, de Castiglione R.
1. The occurrence of sauvagine, a new polypeptide from amphibian skin, and its actions on rat blood pressure and diuresis were studied. 2. Sauvagine was found to be present in the skin of all the 10 Phyllomedusa species so far studied, amounts ranging from a few micrograms to 240 micrograms per g fresh skin. 3. The polypeptide displayed in the rat an intense, long-lasting hypotensive action accompanied by tachycardia. Hypotension was not modified by either atropine or propranolol, excluding the participation of the autonomic nervous system in its production. Tachycardia, on the contrary, was partially inhibited by propranolol. 4. Hypotension is probably the main cause of the intense antidiuresis seen in hydrated rats following sauvagine administration. Reduction in urina volume was accompanied by a decrease in GFR and an increase in tubular NA+ reabsorption.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7402368&dopt=Abstract
Arch Int Pharmacodyn Ther. 1980;Suppl:95-103.
The clinical pharmacology of vasodilator antihypertensive drugs.
O'Malley K, O'Boyle C, Kelly JG, McNay JL, O'Brien ET.
Vasodilator antihypertensive agents are defined and classified according to their mechanism and site of action. The effects of minoxidil, in combination with propranolol and a diuretic, on renal blood flow and renal function were studied following acute and chronic therapy. Although renal blood flow is reduced after two weeks on minoxidil, renal blood flow and renal function are not compromised after one year. The haemodynamic effects and pharmacokinetic profile of acute dosing with tolmesoxide, a new vasodilator antihypertensive agent are described. Results suggest that the long-term efficacy and safety of this drug are worth studying.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7416880&dopt=Abstract
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