Drugs online research references
Anaesthesist. 1980 Jan;29(1):18-25.
[Eeg-effects of promethazine. study on 17 patients (author's transl)]
[Article in German]
Pichlmayr I, Lips U.
Changes in EEG and cEEG were studied in two groups of patients premedicated with promethazine in a dosage of 50 mg iv; study group A consisted of patients whose age ranged from 20-50 years and study group B of patients whose age was above 70 years. The observation time was 15 min but in a few patients only it was extended to 60 min. Changes in behaviour were clinically controlled. Blood pressure and pulse-rate measurements were taken at regular intervals. The first taken base line electroencephalogram patterns of the patients in group A were unremarkable. The recordings of the patients in group B showed a high percentage of deviation from normal. The sedative effect of promethazine showed a widespread individual variation as did also the characteristic changes in EEG frequency bands. Psychomotor side-effects were frequently seen. Characteristic changes in EEG were found to be a continuing 20%-50% decline of alpha amplitude mostly combined with an alternation of stability, or a narrowing of the frequency range in the higher beta band. In addition a light increase of delta and theta activity was observed. Blood pressure and pulse-rate showed a light increase.
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Clin Chem. 1981 Feb;27(2):253-5.
Determination of promethazine in serum by liquid chromatography.
Wallace JE, Shimek EL Jr, Harris SC, Stavchansky S.
We describe a procedure for the liquid-chromatographic determination of promethazine in low-nanogram concentrations in serum. Triflupromazine is used as the internal standard. The method is based on a single extraction of promethazine from serum with hexane and subsequent derivatization with trichloroethyl chloroformate. Analytical recovery of promethazine is about 90%. The lower limit of detection is 1 microgram/L when a 2.0-mL aliquot of serum is assayed. Our data illustrate the practicability of the method for bioavailability studies after oral or rectal administration of promethazine hydrochloride.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7460275&dopt=Abstract
J Pharm Sci. 1983 Jun;72(6):704-5.
Spectrophotometric promethazine hydrochloride determination using bromcresol green.
Emami Khoi AA.
A spectrophotometric method was developed for determining promethazine hydrochloride (I) complexed with bromcresol green and then extracted with chloroform. The complex in chloroform showed maximum absorption at 415 nm and obeyed Beer's law over 1.2-8.5 micrograms/ml. The complex molar absorptivity was 1.93 X 10(4) M. Complex formation and extraction were complete and quantitative over pH 2.7-2.8. The promethazine hydrochloride-bromcresol green molar ratio was 1:1. Excipients, coloring matter, flavoring agents, and other substances likely to be present in promethazine preparations did not interfere in the determination. Direct determination in tablet, syrup, and injection preparations were carried out satisfactorily.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6875836&dopt=Abstract
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