Drugs online research references
J Pharmacol Exp Ther. 1984 Dec;231(3):678-84.
Possible role of calmodulin in the control of lysosomal enzyme release from human polymorphonuclear leukocytes.
Marone G, Poto S, Columbo M, Giugliano R, Genovese A, Condorelli M.
Human polymorphonuclear leukocytes (PMNs) were found to contain a mean +/- S.E.M. of 21.7 +/- 7.9 ng of immunoreactive calmodulin (CaM)/10(6) PMNs, which represents 0.032 +/- 0.001% of the total cellular protein. The functional role of CaM in the control of lysosomal enzyme release from human PMNs was investigated using several CaM antagonists. Trifluoperazine (TFP) (10(-6)-2 X 10(-5) M), pimozide (10(-6)-1.5 X 10(-5) M), chlorpromazine (CPZ) (10(-5)-10(-4) M) and promethazine (2 X 10(-5)-10(-4) M) inhibited in vitro lysosomal enzyme release from human PMNs induced by immunological (serum-treated zymosan, concanavalin A and formyl-L-methionyl-L-leucyl-L-phenylalanine) and nonimmunological (Ca++ ionophore A23187) stimuli. Trifluoperazine sulfoxide (TFP-S) and chlorpromazine sulfoxide (CPZ-S), which have very low affinity for CaM, had practically no inhibitory effect on lysosomal enzyme release. The inhibitory effect of TFP could be made irreversible by irradiating the cells with UV light. A sulfonamide derivative, W-7, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride (10(-5)-2 X 10(-4) M), which selectively binds to CaM, inhibited the release of lysosomal enzymes from PMNs. In contrast, the chloride-deficient analog, W-5, N-(6-aminohexyl)-1-naphthalenesulfonamide hydrochloride, which interacts only weakly with CaM, had practically no inhibiting effect. The IC50 for enzyme release by a series of eight CaM antagonists was closely correlated (r = 0.89; P less than .001) with their affinity for binding to CaM, supporting the concept that these agents act by binding to CaM and thereby inhibiting lysosomal enzyme release.(ABSTRACT TRUNCATED AT 250 WORDS)
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6502522&dopt=Abstract
Acta Anaesthesiol Scand. 1984 Dec;28(6):652-3.
Rectal diazepam compared to intramuscular pethidine/promethazine/chlorpromazine with regard to gastric contents in paediatric anaesthesia.
Blom H, Schmidt JF, Rytlander M.
Sixty children, aged 1-12 years, were investigated with regard to gastric pH and volume before general anaesthesia. Thirty children (group D) received diazepam 0.75 mg/kg b.w. rectally 1 h before anaesthesia. Thirty children (group L) received a "lytic cocktail" (pethidine 28 mg, promethazine 7 mg, chlorpromazine 7 mg per ml) 0.05 ml/kg b.w. intramuscularly 1 h before anaesthesia. The pH values were significantly higher and the amount of gastric juice was significantly lower in group L compared to group D. The number of children in group L with gastric juice volume exceeding 0.4 ml/kg and the number of children with pH less than 2.5 was significantly smaller compared to group D. The number of children with both gastric pH less than 2.5 and gastric juice volume greater than 0.4 ml/kg was significantly smaller in the group receiving "lytic cocktail" intramuscularly compared to the group receiving diazepam rectally. Bile-stained gastric contents was not related to the gastric pH.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6524280&dopt=Abstract
Can J Physiol Pharmacol. 1980 Nov;58(11):1256-61.
Effects of histamine in the isolated kitten heart.
Laher I, McNeill JH.
The effects of histamine and 4-methylhistamine (4-MH) in isolated kitten heart preparations were examined. Histamine and 4-MH produced dose-dependent increases in the rate of spontaneously beating right atria. The positive chronotropic effect of histamine and 4-MH was unaffected by promethazine but was antagonized by both cimetidine and propranolol. The positive inotropic effects of histamine and 4-MH were studied in the kitten right ventricle strip, right papillary muscle, and left atrium. In all three tissues the positive inotropic effect of histamine and 4-MH was blocked by propranolol and not by either promethazine or cimetidine. In tissues from reserpine-pretreated kittens, histamine caused only a modest increase in rate. The inotropic effects of histamine in the left atrium, right ventricle strip, and right papillary muscle were abolished following reserpine pretreatment. The results of this study indicate two components to the effects of histamine and 4-MH on the kitten heart. The majority of the chronotropic response, and all of the inotropic response, is due to indirect activation of beta adrenoceptors through release of catecholamines. Part of the chronotropic response to both histamine and 4-MH is due to histamine H2-receptor stimulation. Based on the results from reserpine-pretreated animals, it is possible that the release of catecholamines by histamine in the kitten right atrium is through H2-receptor stimulation.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7214199&dopt=Abstract
Herbs and Pharmaceuticals Online ||
Hair Million herbal formula for hair loss and hair growth ||
Wellstreet online pharmacy for click-order prescription medications ||
Altace Online Pharmacy ||
Rx Drugs USA, Prescription Drugs Online Pharmacy ||
Insurance plans and information ||
Insurance policies for all purposes ||
Antibiotics and prescription medications online literature ||