Drugs online research references
Ann Allergy. 1978 Oct;41(4):216-9.
Chronic rhinitis in the pre-school child.
Hyde JS, Arora NV, Kumar CM, Moore BS.
The etiologic role of atopy in chronic rhinitis in 40 infants and pre-school children was investigated and the long-term effectiveness and safety of promethazine studied during six to 48 months. Twenty children were clearly atopic and 16 were not. Four had incomplete laboratory evidence of atopy. In addition to clinical histories and physical findings, the subjects were evaluated by skin tests for common allergens. RAST tests, total IgE levels and absolute eosinophil counts. Promethazine in doses of 3 to 12 mg/kg/day (mean 8 mg) was administered in divided doses, four times a day for perennial rhinitis and on "as required" basis for recurrent and seasonal rhinitis. Side effects included drowsiness and irritability, which led to discontinuance of promethazine in one subject. There was no laboratory evidence of hematologic, renal or hepatic abnormalities. Promethazine was found to be an effective agent for symptom-control of chronic rhinitis in the pre-school child.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=568438&dopt=Abstract
Minerva Anestesiol. 1980 Feb;46(2):241-4.
[Changes in intraocular pressure in anesthesia induced with althesin and maintained with methoxyflurane]
[Article in Italian]
Barbieri O, Pascali F, Piva R, Zattoni J.
Intraocular pressure and arterial blood pressure were studied in 27 patients undergoing anaesthesia induced by 0,6-1 mg/kg of Althesin iv and maintained by methoxyflurane-N2O-O2 on spontaneous ventilation. All patients were scheduled to undergo various types of eye surgery, including open-eye surgery. Patients with glaucoma and cataract were administered 20% mannitol two hours prior to surgery. In all cases premedication was based on meperidine, promethazine and atropine sulphate im. During the entire period of anaesthesia the intraocular pressure and, generally, arterial blood pressure appeared to be lowered.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7453992&dopt=Abstract
J Appl Physiol. 1985 Jul;59(1):39-46.
Promethazine or DPPD pretreatment attenuates oleic acid-induced injury in isolated canine lungs.
Townsley MI, Taylor GE, Korthuis RJ, Taylor AE.
Oleic acid causes pulmonary edema by increasing capillary endothelial permeability, although the mechanism of this action is uncertain. We tested the hypothesis that the damage is an oxidant injury initiated by oleic acid, using isolated blood-perfused canine lung lobes. The lobes were dilated with papaverine and perfused in zone III with a constant airway pressure of 3 cmH2O. Changes in isogravimetric capillary pressure (Pc,i) and capillary filtration coefficient (Kf,C) were used as indices of alterations in microvascular permeability in lungs treated with silicone fluid (n = 3), oleic acid (n = 11), oleic acid after pretreatment with the antioxidants promethazine HCl (n = 11) or N,N'-diphenyl-p-phenylenediamine (DPPD; n = 4), or oleic acid following pretreatment with methylprednisolone (n = 4). Kf,C averaged 0.21 +/- 0.02 ml X min-1 X cmH2O-1 X 100 g-1 in control and increased to 0.55 +/- 0.05 and 0.47 +/- 0.05 when measured 20 and 180 min after the administration of oleic acid. When oleic acid was infused into lungs pretreated with promethazine, Kf,C increased to only 0.38 +/- 0.05 ml X min-1 X cmH2O-1 X 100 g-1 after 20 min and had returned to control levels by 180 min. Pretreatment with DPPD, but not methylprednisolone, similarly attenuated the increase in Kf,C following oleic acid. Silicone fluid had no effect on Kf,C. That oleic acid increases vascular permeability was also evidenced by a fall (P less than 0.05) in Pc,i from control when measured at 180 min in every group.(ABSTRACT TRUNCATED AT 250 WORDS)
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=4030577&dopt=Abstract
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