Drugs online research references
Experientia. 1979 Nov 15;35(11):1430-1.
Effects of several preoperative medications on fat cell lipolysis, and activity of adipose tissue cyclic AMP phosphodiesterase.
Curtis-Prior PB, Jenner M, Chan YH, McColl I.
Effects were examined of atropine, diazepam, pethidene, promethazine, scopolamine, omnopon and papaverine on basal and noradrenaline-stimulated lipolysis in rat isolated fat cells and on rat adipose tissue cyclic AMP phosphodiesterase activity. Papaverine at high concentration (1 mM) inhibited both basal and hormone-stimulated lipolysis, whereas diazepam enhanced basal lipolysis. At a 'clinical dose', omnopon increased both basal and noradrenaline-stimulated lipolysis. Adipose tissue cAMP phosphodiesterase activity was strongly inhibited by 1 mM diazepam, papaverine, promethazine and omnopon (280 microgram ml-1). Lack of enhancement of lipolysis by the established cAMP phosphodiesterase antagonist papaverine, is compatible with simultaneous inhibition also of adipose adenyl cyclase. Diazepam-stimulated lipolysis is compatible with its phosphodiesterase inhibitory activity. It is proposed that papaverine-containing omnopon may offer some survival advantages during surgical stress by facilitating a caloric supply.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=228965&dopt=Abstract
ASDC J Dent Child. 1975 Nov-Dec;42(6):453-9.
A study of three preoperative sedative combinations.
Tobias M, Lipschultz DH, Album MM.
The use of drugs as premedication for child patients to be treated in the office may provide the dentist with an adequate means of controlling the patient otherwise incapable of cooperation. Drug dosages for children cannot be determined alone on the basis of weight and age, especially when dental treatment is to be provided. Alphaprodine and promethazine; chloral hydrate and hydroxyzine pamoate; pentobarbital, meperidine, and scopolamine are three groups of balanced medication that fulfill the needs in pedodontic office procedures. The Pedi-Wrap is an important factor in treatment and control of movements unknowingly exhibited by the patient from one to six years of age. Its use should be required for the very young child patient, to prevent falls and bodily injury and to allow the doctor to execute his treatment effectively.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1107370&dopt=Abstract
Am J Physiol. 1990 Sep;259(3 Pt 2):R507-13.
Brain histamine regulates pressor responses to peripheral hyperosmolality.
Akins VF, Bealer SL.
Department of Physiology, University of Tennessee, Memphis 38163.
The role of brain histamine (HA) in the pressor response to peripheral hyperosmolality was investigated in the conscious Sprague-Dawley rat. Increased mean arterial pressure was observed during a 30-min intravenous infusion of hypertonic saline (HTS; 10 microliters.100 g body wt-1 x min-1) in vehicle-treated controls (20.1 +/- 3.8 mmHg) and in animals centrally pretreated with the specific H2-antagonist, cimetidine (15.0 +/- 3.7 mmHg). However, this pressor response was abolished in a dose-dependent manner after intracerebroventricular injection of the H1 antagonist promethazine. In other experiments, brain tissue microdissected from the supraoptic nucleus (SON), paraventricular nucleus (PVN), and posterior hypothalamic region showed significantly lower levels of total tissue HA after 60 min of intravenous HTS infusion compared with tissue taken from control animals receiving an isotonic infusion. Microdialysis in the region of the PVN or SON before and during HTS infusion showed increased extracellular concentrations of HA in the SON (24.4 +/- 10.9%) during infusion. No change in extracellular HA concentration was seen in the PVN during HTS infusion. These results support the conclusion that endogenous brain HA is involved in the pressor response to peripheral hyperosmolality.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2396709&dopt=Abstract
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