Drugs online research references
Fertil Steril. 1973 Dec;24(12):935-40.
Postoperative intraperitoneal adhesions: a double-blind assessment of their prevention in the monkey.
Seitz HM Jr, Schenker JG, Epstein S, Garcia CR.
PIP: The effect of combined antihistamine and corticosteroid therapy and the effect of dextran on recurrent intraperitoneal adhesion formation were evaluated in 43 monkeys, all of which had been previously used for reproductive tract studies, and, hence, were suffering from adhesion formation to some degree. In a double-blind manner, the monkeys were randomly divided into 3 experimental groups. 1 group received saline injections before and after lysis surgery followed by introduction of saline solution in the peritoneum during surgery. Group 2 was treated with saline injections, as Group 1, except that dextran solution was introduced into the peritoneal cavity. In Group 3, a combined dexamethasone/promethazine therapy was administered before, during, and after surgery. In all of these monkeys, the degree of adhesion reformation after adhesion lysis surgery was essentially the same in all 3 groups. Rather, careful surgical technique was vastly more important than use of corticosteroids or antihistamines as prophylactic measures.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=4202271&dopt=Abstract
Aust N Z J Obstet Gynaecol. 1982 Nov;22(4):215-7.
Fetal distress due to intravenous administration of pethidine (meperidine) with promethazine during labour.
Bergman A, Eckstein N, Yedwab G, David MP.
Fetal bradycardia due to uterine hypertonia was observed after the intravenous administration of pethidine (meperidine) 75 mg with promethazine 25 mg during active labour. These analgesic drugs are known to affect uterine contractions by enhancing both amplitude and frequency, but are thought to affect uterine tone minimally. Twenty cases of uterine hypertonia resulting in fetal bradycardia were monitored in a period of 6 months in women receiving these drugs during labour. In all cases, the uterine hypertonia appeared shortly after the drug administration. The uterine hypertonus as well as the fetal bradycardia were self limited and no intervention was undertaken. Recognition of this phenomenon is important in order to prevent unnecessary anxiety on the part of medical attendants.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6963160&dopt=Abstract
Pharmacology. 1981;22(5):305-10.
Lack of histamine involvement in parathyroid hormone hypotensive action.
Yang MC, Tenner TE Jr, Pang PK.
Promethazine and cimetidine blocked the hypotensive actions of 2-pyridylethylamine, and H1 agonist and dimaprit, an H2 agonist, respectively, but not that of bovine parathyroid hormone fragment [bPTH-(1-34)]. Rats were treated repeatedly with the histamine releaser, compound 48/80, until the release could no longer produce a decrease in blood pressure. The hypotensive action of bPTH-(1-34) could still be seen. Rats with histamine partially depleted with one injection of compound 48/80 were injected with cimetidine and pyrilamine, and H1 antagonist, which together blocked the hypotensive action of subsequent injections of compound 48/80, but not that of bPTH-(1-34). These data suggest that the vasodilatory action of bPTH-(1-34) does not involve the release or action of histamine.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6454897&dopt=Abstract
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