Drugs online research references
Can J Surg. 1993 Jun;36(3):225-8.
Intravenous regional anesthesia in the treatment of forearm and wrist fractures and dislocations in children.
Colizza WA, Said E.
Department of Surgery, McGill University, Montreal, Que.
OBJECTIVE: To evaluate the efficacy and safety of intravenous regional anesthesia in the treatment of unilateral closed fractures and dislocations of forearm or wrist in children. DESIGN: A prospective study over 6 years. SETTING: The study was undertaken in the well-equipped emergency department of a community general hospital for ambulatory patients. PATIENTS: One hundred and thirty-nine children between the ages of 4 and 18 years with unilateral closed fractures and dislocations of forearm or wrist. INTERVENTION: All children received premedication with a combination of meperidine and promethazine (0.5 mg/kg intramuscularly) and regional upper limb anesthesia with 0.5% lidocaine solution (3 mg/kg intravenously) after inflation of an arm tourniquet. MAIN OUTCOME MEASURES: The relief of pain, allowing closed reduction with intravenous regional anesthesia, and the incidence of complications. RESULTS: All patients had complete relief of pain allowing successful closed reduction in 133 patients (96%); tourniquet pain occurred in 10 patients (7%). There were no symptoms of lidocaine toxicity. There were no neurovascular or compartment syndrome complications. CONCLUSIONS: Intravenous regional anesthesia for the treatment of fractures and dislocations of forearm and wrist in children was found to be simple, safe and effective.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8324666&dopt=Abstract
Farmakol Toksikol. 1977 Mar-Apr;40(2):158-62.
[Phencarol--an antihistaminic preparation from the quinuclidylcarbinol group]
[Article in Russian]
Kaminka WE.
A high antihistaminic activity of quinuclidyl-3-diphenylcarbinol (phencarol) has been ascertained. In pharmacological experiments phencarol is superior to dimedrol (diphenhydramine), both as concerns its antihistaminic activity and the duration of its action. Unlike dimedrol and diprazine (promethazine) it has no inhibitory effect on the central nervous system. With its clinical use phencarol is effective in treating urticaria, Quincke's edema and allergic skin reactions. The drug is well tolerated by the patients and does not produce any inhibitory or soporific action. Phencarol has an authorized permission to be used for medical purposes.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15861&dopt=Abstract
Lancet. 1979 Jan 20;1(8108):130-1.
Survival of heart allografts in rats treated with azathioprine and sodium salicylate.
Jamieson SW, Burton NA, Reitz BA, Stinson EB.
In a rat heart transplant model representing a severe mismatch, median survival time (M.S.T.) with no treatment was 6 days. M.S.T. with azathioprine was 6 days, and with azathioprine and methylprednisolone 7 days. Azathioprine with promethazine hydrochloride gave an M.S.T. of 15 days. In rats treated with sodium salicylate alone M.S.T. was 16 days, and when azathioprine was administered for 12 days in a group continuously treated with sodium salicylate, all hearts were beating normally at 50 days.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=84152&dopt=Abstract
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