Drugs online research references
Biochem J. 1983 Jul 15;214(1):225-30.
Differential control of insulin secretion and somatostatin-receptor recruitment in isolated pancreatic islets.
Sussman KE, Pollard HB, Leitner JW, Nesher R, Adler J, Cerasi E.
Somatostatin receptors appear to be localized to secretory granules in pancreatic islet homogenates. Recruitment of these receptors to the islet-cell surfaces may mark the contact event between secretory granules and plasma membranes before release of insulin by fission. Isethionate, an impermeant anionic replacement for chloride, blocks the release step but does not affect receptor recruitment. By contrast, low concentrations of phenothiazine drugs, such as trifluoperazine and promethazine, inhibit both receptor recruitment and secretion. Scatchard analysis of phenothiazine effects on somatostatin receptors reveals that these drugs reduce the number of receptors but do not affect the affinity of the receptor for somatostatin. These data indicate that membrane contact and fission steps during exocytosis can be biochemically separated.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6311175&dopt=Abstract
Pharmazie. 1985 May;40(5):331-2.
[Determination of aminophylline and promethazine in suppositories]
[Article in German]
Senf HJ.
A method for the determination of theophylline and promethazine in suppositories is proposed which allows the determination of both components in a single suppositorium. The ingredients were extracted by hot water and addition of a little bit of sulfuric acid. Theophylline is determined potentiometrically without separation of promethazine by titrating the acid which is set free after addition of silver nitrate. Promethazine is separated by ether in alkaline medium, reextracted in HCl (0,1 mol/l) and determined colorimetrically. The precision of both methods is good. The results of the determination in the suppositories are given.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=4034638&dopt=Abstract
Fertil Steril. 1991 Feb;55(2):389-94.
Synergistic effects of INTERCEED(TC7) and heparin in reducing adhesion formation in the rabbit uterine horn model.
Diamond MP, Linsky CB, Cunningham T, Kamp L, Pines E, DeCherney AH, diZerega GS.
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06510.
Surgical adjuvants are commonly employed to reduce the frequency of postoperative adhesion development after reproductive pelvic surgery. The ability of indomethacin, promethazine dexamethasone, Intralipid, progesterone, and heparin to reduce adhesion formation in combination with INTERCEED(TC7) (Johnson and Johnson Medical, Inc., New Brunswick, NJ), an absorbable barrier that alone reduces adhesion formation, was examined in a rabbit uterine horn model. A significant reduction in adhesion formation was only observed with the combination of INTERCEED(TC7) plus heparin. In addition studies, heparin delivery by intraperitoneal (IP) lavage, intravenous injection, or intra-abdominal instillation failed to demonstrate efficacy. Similarly, heparin delivery with other barriers or IP instillates (carboxymethylcellulose or 32% Dextran 70) failed to reduce adhesion formation. We conclude that INTERCEED(TC7) can be efficaciously utilized as a carrier to deliver heparin to traumatized surfaces, thereby reducing adhesion formation.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1991536&dopt=Abstract
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