Drugs online research references
Jpn J Pharmacol. 1982 Oct;32(5):909-19.
Effects of anti-inflammatory drugs on triple vaccine-induced pleurisy in rats.
Satoh H, Shimomura K, Mukumoto S, Ohara K, Mori J.
Effects of various anti-inflammatory drugs on triple vaccine-induced pleurisy, a model of delayed hypersensitivity, were examined and compared with those on carrageenin-induced pleurisy in rats. Steroidal drugs depressed markedly the volume of exudate and the number of leucocytes in both types of pleurisy. Gold compounds also depressed both types of pleurisy. Non-steroidal anti-inflammatory drugs were apt to show depressive effects on carrageenin-induced pleurisy, especially on increased exudate volume. BW755C produced a depressive effect on carrageenin-induced pleurisy, but on triple vaccine-induced pleurisy, BW755C produced only a slight depressive effect. Cyproheptadine produced a slight depressive effect on carrageenin-induced pleurisy, but not on triple vaccine-induced pleurisy. Promethazine had a slight depressive effect on both types of pleurisy. D-penicillamine and levamisole did not show any depressive effects on triple vaccine-induced pleurisy. The results show that reported mediators in carrageenin-induced pleurisy (prostaglandin, serotonin, leukotriene B, etc.) are not relevant to triple vaccine-induced pleurisy. Specific lymphokines and/or degradated products of complement may participate in the latter. This triple vaccine-induced pleurisy seems to be a good model for screening non-steroidal anti-inflammatory drugs which have steroidal-like activity.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7176223&dopt=Abstract
Pflugers Arch. 1980 Sep;387(2):115-20.
Inhibition of Ca2+-activated tension and myosin light chain phosphorylation in skinned smooth muscle strips by the phenothiazines.
Cassidy P, Hoar PE, Kerrick WG.
The antipsychotic phenothiazine drugs trifluoperazine, chlorpromazine, and promethazine inhibited Ca2+-activated tension in functionally skinned rabbit ileum and rabbit pulmonary artery strips. Exogenous calmodulin rapidly reversed the inhibition of tension. Inhibition of the endogenous myosin light chain kinase by these drugs resulted with ATP or its analog. ATP gamma S, as a substrate. The evidence presented suggests the inhibition of Ca2+ activation of tension in skinned smooth muscle preparations by phenothiazines is due to the inhibition of Ca2+-activated phosphorylation of the 20,000 dalton myosin light chain by the endogenous myosin light chain kinase.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7191975&dopt=Abstract
Eur J Pharmacol. 1982 May 21;80(2-3):171-84.
Bronchodilator and antiallergic effects of thiazinamium chloride in guinea pigs, rats, cats and dogs.
Lewis AJ, Dervinis A, Rosenthale ME.
This study characterized the in vivo pulmonary pharmacology of thiazinamium chloride administered largely by the aerosol route in different animal species. The compound has greater anticholinergic but weaker antihistaminic activity than promethazine, the parent compound. It was less potent than atropine or ipratropium as an anticholinergic and had a shorter duration of action, but unlike these compounds it had long-lasting antihistaminic activity. It is effective in both IgG- and IgE-induced models of passive lung anaphylaxis in guinea pigs and rats, respectively. In Ascaris-induced allergic asthma in the conscious dog it produced a dose-related inhibition of the antigen-induced bronchospasm. No major side effects were observed in acute oral and inhalation toxicity studies in guinea pigs or rhesus monkeys. The results demonstrate that thiazinamium chloride is a safe, potent and efficacious bronchodilator after aerosol administration, with a rapid onset and moderate duration of action in animal models.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6125398&dopt=Abstract
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