Drugs online research references
Farmakol Toksikol. 1989 Sep-Oct;52(5):31-3.
[The effect of antihistamine preparations on the contraction of the isolated guinea pig ureter]
[Article in Russian]
Kaminka ME, Zhirnikova ML.
The effect of antihistaminics on contractions of the isolated guinea pig ureter was studied. The ureter contractions induced by histamine were prevented by H1-blockers: pipolphen (promethazine), dimedrol (diphenhydramine), phencarol (quifenadine), suprastin (chloropyramine), cyproheptadine and H2-blockers: cimetidine, ranitidine. Electric stimulation-induced contractions were prevented by suprastin. Phencarol, tavegil, cimetidine, ranitidine didn't act on the contractions. The electrically induced contractions were potentiated by pipolphen, dimedrol, cyproheptadine.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2480912&dopt=Abstract
J Pharm Pharmacol. 1989 Nov;41(11):792-4.
Factors in snake venoms that increase capillary permeability.
Miller RA, Tu AT.
Department of Biochemistry, Colorado State University, Fort Collins 80523.
Capillary permeability increasing (CPI) activity is a phenomenon of the microvasculature caused by many agents such as snake venoms, histamine, 5-hydroxytryptamine (5-HT), prostaglandins and leukotrienes. Since no systematic study has been done to determine what components of snake venom cause CPI activity, a CPI factor from Naja naja atra (Taiwan cobra) venom was isolated using intravenous injections of Evan's blue dye as the indicator of increased permeability and the factor's properties were extensively studied. Cardiotoxin from Naja naja kaouthia (Thailand cobra) and Mojave toxin from Crotalus scutulatus scutulatus (Mojave rattlesnake) venoms demonstrated CPI activity. Postsynaptic neurotoxins from an elapid and a hydrophid and myotoxin a from Crotalus viridis viridis (prairie rattlesnake) showed no CPI activity at the dose studied. The purified CPI active component from Naja naja atra venom was found to have cardiotoxic activity. Therefore, Elapidae cardiotoxins are CPI active factors. However, CPI activity is not due to cardiotoxins alone as the presynaptic neurotoxin, Mojave toxin, also showed CPI activity. Selective inhibitors were used to indicate possible mechanisms of action on the capillaries by Naja naja atra venom and Crotalus scutulatus scutulatus venom. The histamine H1-receptor blockers diphenhydramine, promethazine, and cyproheptadine were effective against both venoms in preventing increased capillary permeability. These results suggested that histamine release activity is the most likely mechanism resulting in CPI activity from these venoms.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2576052&dopt=Abstract
Yao Xue Xue Bao. 1989;24(11):853-8.
[P-matrix spectrophotometric determination of 6 components contained in compound reserpine tablets]
[Article in Chinese]
Xu JP, Xiang BR, An DK.
P-matrix method has been developed for the simultaneous determination of vitamin B1, vitamin B6, chlordiazepoxide, dihydralazins sulfate, promethazine hydrochloride and hydrochlorothiazide contained in compound reserpine tablets consisting of 10 components. The optimal wave-length for measurement was successfully selected based on the principle of condition number. The influence of experimental error, number of wavelength and condition number deviation of component concentration from formula were discussed. The average recoveries varied from 97-103% with CV less than or equal to 9.5% (n = 11).
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2618684&dopt=Abstract
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