Drugs online research references
Am J Gastroenterol. 1992 Aug;87(8):961-6.
Optimizing the information obtained from continuous 24-hour gastric pH monitoring.
Mela GS, Savarino V, Vigneri S.
Dipartimento di Medicina Interna, Universita di Genova, Italy.
Our objective in performing this study was to determine the best way to summarize experimental data obtained from 24-h continuous intragastric pH-metry. For this purpose, we reviewed 605 circadian intragastric pH recordings performed under different clinical conditions. Included were 82 normal subjects, 126 patients with active duodenal ulcer, 272 ulcer patients in clinical remission treated with a single bedtime dose (at 10 PM) of various H2 antagonists and 125 patients with active ulcer treated with a single morning dose (8 AM) of omeprazole. For each group, we calculated the time spent at different pH levels scaled with 0.1 incremental steps in three different time intervals: 24 h (5 PM to 4:59 PM), daytime (8 AM to 7:59 PM), and nighttime (8 PM to 7:59 AM). Then we calculated the mean and the median pH, as well as the time spent in min greater than 3.0 pH units over a mainly drug-related time window (8 PM to 7:59 AM) for each treatment and its respective placebo group. The mean and the median pH, as well as the time spent in minutes greater than 1.2 pH units over 24 h were also calculated for the untreated groups of normal subjects and duodenal ulcer patients. Considering the individual pH recordings, bi- or plurimodal density distributions of pHs were found in more than 90% of the 605 subjects, no matter the time window and the clinical condition examined, and log-normal distributions were found in only three cases. Considering the groups instead of single pH recordings, conversely, normal subjects and duodenal ulcer patients showed average left-skewed unimodal density distributions, whereas bimodal patterns were the rule in the groups of patients treated with H2 antagonists and omeprazole. The time spent greater than 3.0 pH units was the most powerful acidity index in assessing drug effectiveness in the various subsets of antisecretory compounds, in that the Student's t test values obtained with this variable were almost invariably higher than those obtained with the mean and median pH levels. Also, the time spent greater than 1.2 pH units was the most powerful summary variable in differentiating normal subjects from duodenal ulcer patients (p less than 0.01, compared with the mean and median pH). We conclude that the time spent above a given pH threshold of interest is a more accurate index than the mean and median pH in summarizing gastric acidity changes under all clinical conditions, and this is because it better represents the experimental pH measurements from which it comes.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1353661&dopt=Abstract
note: kwd match prilosec online literature
Ross Gastroenterol Zh. 2001;(1):45-54.
[Results of child observation during 3 years after the eradication treatment]
[Article in Russian]
Kornienko EA, Antonova PV.
Comparative evaluation of clinical, endoscopic and morphological stomach mucosa changes dynamics was performed in 100 patients with presence and absence of HP eradication during 3 years. Improvement of clinical, endoscopic and disease morphological sings, sometimes the complete its normalization, but never worsening were observed in the most patients with HP eradication. The main pathomorphological indexes were for certain decreased after 1 year of eradication. The same indexes were not changed in the patients with still presence of HP infection. The complete normalization of stomach mucosa morphology was revealed in 28% of children during 3 years after HP eradication. New HP infection and recurrence of complains and increase of inflammatory and dystrophic stomach mucosa changes were revealed in 43% of children.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11565124&dopt=Abstract
note: kwd match prilosec online literature
Aliment Pharmacol Ther. 1990 Oct;4(5):485-95.
Combined gastric and oesophageal 24-hour pH monitoring and oesophageal manometry in patients with reflux disease, resistant to treatment with omeprazole.
Klinkenberg-Knol EC, Meuwissen SG.
Department of Gastroenterology, Free University Hospital, Amsterdam, The Netherlands.
Combined oesophageal and gastric 24-hour pH monitoring and oesophageal manometry were performed in 19 patients with resistant reflux oesophagitis after short-term therapy with omeprazole (40 to 60 mg daily) or during maintenance treatment with omeprazole (20 to 80 mg daily). Omeprazole's effects on acidity were analysed as well as any possible influence on oesophageal motility. A pH in the stomach of below 4 was present during considerable periods of time (in 27 of 29 measurements), particularly during the night. As a consequence, pathological gastro-oesophageal reflux occurred, particularly in the supine period. Insufficiency of the lower oesophageal sphincter was present in all but one patient; decreased or virtually absent motility of the oesophagus was found in 63% of the patients. Combined intragastric and intra-oesophageal pH monitoring, with oesophageal manometry, may contribute to the management of patients with reflux disease resistant to treatment with omeprazole. The present study emphasizes the need to individualize therapy in patients with refractory gastrooesophageal reflux disease.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2129636&dopt=Abstract
note: kwd match prilosec online literature
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