Drugs online research references
J Toxicol Clin Toxicol. 1997;35(1):55-61.
Does concurrent acute ethanol ingestion during omeprazole therapy affect pituitary gonadal axis in male subjects?
Mokshagundam SL, Minocha A.
University of Louisville, Kentucky, USA.
OBJECTIVE: Literature suggests that both ethanol and omeprazole may affect the endocrine system. We studied the effect of concurrent use of ethanol and omeprazole on the pituitary gonadal axis in healthy males. METHODS: Serum testosterone, luteinizing hormone, and follicle stimulating hormone levels were assessed in a fasting state before and after ingestion of 0.5 g/kg bodyweight of ethanol. Subjects then received omeprazole therapy (20 mg 2x/d for one week) followed by assessment of hormone levels before and after ethanol ingestion as done previously. RESULTS: Total testosterone levels before and after ethanol at baseline declined an average of 46.6 ng/dL (n = 8; p = NS). The testosterone levels before and after ethanol following omeprazole therapy rose an average of 55.4 ng/dL (n = 8; p = NS). There was no significant difference in the change of ethanol induced testosterone concentrations as a result of omeprazole therapy. Similarly the free testosterone, follicle stimulating hormone, and luteinizing hormone were also not affected by ethanol or omeprazole alone or in combination. CONCLUSIONS: We conclude that omeprazole and/or acute ingestion of ethanol do not affect the pituitary gonadal axis in healthy male subjects.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9022653&dopt=Abstract
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Z Gastroenterol. 1988 Mar;26(3):188-90.
Effect of omeprazole on ethanol oxidation and aniline hydroxylation in rat hepatic microsomes.
Seitz HK, Simanowski UA, Simon B, Kommerell B.
Alcohol Research Laboratory, Department of Medicine, University of Heidelberg, F.R.G.
Omeprazole, a substituted benzimidazole, is a potent gastric acid antisecretory drug, which inhibits the hepatic oxidative drug metabolism in vitro and in vivo. The effect of omeprazole on the microsomal ethanol oxidizing system (MEOS) and, since ethanol-induced cytochrome P-450 reveals a high activity for aniline hydroxylation, on aniline hydroxylase (AH) has been investigated in rat liver microsomes. Omeprazole inhibits microsomal AH activity significantly in a dose dependent manner, while this was not the case for MEOS activity. These data give indirect evidence that the microsomal metabolism of both ethanol and aniline is mediated by different isoenzymes of cytochrome P-450 and that omeprazole exhibits a different affinity to both compounds. Therefore, it must be emphasized that drug interactions with omeprazole have to be tested experimentally in each individual case, since it is impossible to predict such interactions solely on the knowledge of the drug's metabolic pathway.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3043944&dopt=Abstract
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Toxicol Lett. 2000 Dec 20;118(1-2):21-30.
Effects of omeprazole on ethanol lesions.
Abdel Fattaha NA, Abdel-Rahman MS.
Anatomy Department, Faculty of Medicine, Menoufiya University, Egypt.
Male Sprague-Dawley rats were used to study the effects of omeprazole on normal and ethanol damaged gastric mucosa, and to estimate plasma gastrin levels following the administration of omeprazole for 2 weeks. The dosage of omeprazole was 50 mg/kg body weight, once daily via gavage. In omeprazole treated animals, serum gastrin levels showed statistically significant increases compared with the control and ethanol treated animals. Our results indicate that omeprazole has no protective effect on ethanol-induced alterations in gastric mucosa and, in fact, appears to produce worsened lesions. In achlorohydric doses, omeprazole can induce significant gastrin levels with consequent hypertrophy and hyperplasia of enterochromaffin-like cells and somatostatin cells. It is believed that this powerful drug should be reserved for patients who are refractory to standard H(2)-receptor antagonist therapy.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11137305&dopt=Abstract
note: kwd match prilosec online literature
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