Drugs online research references
Pharmacol Toxicol. 1997 Dec;81(6):247-52.
Lansoprazole and ethanol metabolism: comparison with omeprazole and cimetidine.
Battiston L, Tulissi P, Moretti M, Pozzato G.
Institute of Clinical Medicine, University of Trieste, Italy.
Since some antisecretory drugs such as cimetidine and ranitidine, interfere with ethanol metabolism by inhibition of hepatic and/or gastric alcohol dehydrogenase, we investigated the effect of lansoprazole, a new protonic pump inhibitor, on gastric and hepatic alcohol dehydrogenase activity. We also compared the lansoprazole effect with that of omeprazole and cimetidine, respectively. Ethanol blood concentration after oral intake or intravenous administration of ethanol was estimated either in normal male human volunteers or in male rats before and after one week pretreatment with lansoprazole, omeprazole and cimetidine. Furthermore, the in vitro effect of these drugs was studied on both human and rat gastric and hepatic alcohol dehydrogenases. Finally, we measured the effect of the treatment on the reduced hepatic glutathione to test the effects of the drugs on first-pass metabolism of ethanol. The results reported in this paper indicate that lansoprazole, as well as omeprazole, does not affect ethanol metabolism, and that protonic pump inhibitors seem to be safer than imidazole-derived drugs in subjects unable to reduce ethanol intake during conditions requiring acid secretion inhibition.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9444664&dopt=Abstract
note: kwd match prilosec online literature
Am J Gastroenterol. 1996 Nov;91(11):2347-54.
Relevance of the ferret model of Helicobacter-induced gastritis to evaluation of antibacterial therapies.
Alder JD, Ewing PJ, Mitten MJ, Oleksijew A, Tanaka SK.
Abbott Laboratories, Abbott Park, Illinois, USA.
OBJECTIVES: The goals of the study were 1) to evaluate the efficacy of clinically relevant antibacterial therapies in the ferret model of Helicobacter-induced gastritis and 2) to compare these results to the efficacy achieved clinically in humans. METHODS: Ferrets were inoculated with H. mustelae, and gastritis was allowed to develop. The double therapy of clarithromycin and omeprazole and the triple therapies of clarithromycin or amoxicillin with metronidazole and omeprazole were administered. Efficacy was evaluated by Helicobacter burden cultured from biopsy samples and by histopathological evaluation of Helicobacter burden and gastric inflammation with pylorus and fundus samples obtained 4 wk after the end of antibacterial therapy. RESULTS: Clarithromycin-based double and triple therapies significantly reduced Helicobacter burden and decreased gastric inflammation. Clarithromycin-based double therapy was more effective than amoxicillin-based triple therapy. Reduction of the length of clarithromycin therapy from 14 to 7 days decreased efficacy. Antibacterial therapies in the ferret did not produce eradication rates comparable to clinical results, even though the serum concentrations of clarithromycin in ferret were in excess of concentrations used in humans. Relapse of Helicobacter infection after the end of therapy occurred in some cases. CONCLUSIONS: Although the ferret model of Helicobacter gastric infection underestimated the clinical efficacy of antibacterial treatments in humans, the model was valuable for comparing the relative efficacy of antibacterial therapies.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8931416&dopt=Abstract
note: kwd match prilosec online literature
Am J Gastroenterol. 1996 Oct;91(10):2110-3.
Prolonged ambulatory pH monitoring in patients with persistent gastroesophageal reflux disease symptoms: testing while on therapy identifies the need for more aggressive anti-reflux therapy.
Katzka DA, Paoletti V, Leite L, Castell DO.
Department of Medicine, Graduate Hospital, Philadelphia, Pennsylvania, USA.
Patients with gastroesophageal reflux disease (GERD) who remain symptomatic despite receiving a moderate dose of a proton pump inhibitor need accurate assessment to determine who will respond to high doses of the drug or even need surgery. AIM: To determine if prolonged ambulatory pH monitoring performed in patients with persistent symptoms potentially due to GERD while on therapy could predict which patients are likely to benefit from more aggressive anti-reflux therapy. METHODS: Ambulatory pH studies were reviewed for 45 patients with continuing reflux-type symptoms while on 20 mg omeprazole b.i.d. Patients were separated by typical symptoms (heartburn) versus atypical symptoms (chest pain, asthma, hoarseness, cough, throat burning) and for degree of symptom association with episodes of reflux during pH monitoring (symptom index). Control of esophageal acid exposure by omeprazole was defined as distal esophageal pH < 4 < 1.6% total time. RESULTS: Of these 45 patients, 14 (31%) had acid reflux that was not controlled by omeprazole 20 mg b.i.d. Thirty-six patients had atypical symptoms of GERD, and 10 of these patients had poorly controlled reflux. Of these 10 patients, only one patient responded to omeprazole 20 mg q.i.d. In the other nine patients, omeprazole at the higher dose controlled the reflux (documented by pH monitor), but symptoms persisted with poor association to reflux. Thus, only one out of 36 patients with atypical symptoms had subsequent improvement in symptoms. Nine patients had persistent, typical GERD symptoms, and five of these patients had poorly controlled GER. The three patients with good symptom correlation and poorly controlled reflux all responded to increased omeprazole whereas the two with poor symptom association did not. One patient with good control of reflux but good correlation of the remaining reflux to persistent symptoms also responded symptomatically to 80 mg of omeprazole. CONCLUSION: By assessing symptom correlation to reflux episodes and control of reflux by therapy, ambulatory pH monitoring performed in patients with persistent symptoms potentially due to reflux while on therapy gives valuable information concerning further treatment strategies.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8855731&dopt=Abstract
note: kwd match prilosec online literature
Herbs and Pharmaceuticals Online ||
Hair Million herbal formula for hair loss and hair growth ||
Antibiotics and prescription medications online literature ||