Drugs online research references
Dis Esophagus. 2001;14(1):17-22.
Adenocarcinoma of the rat esophagus in the presence of a proton pump inhibitor: a pilot study.
Moore KH, Barry P, Burn J, Falk G.
Department of Surgery, University of Sydney, Australia.
This study examines the effects of a proton pump inhibitor on a rat model of duodenogastric reflux. Duodenoesophageal reflux was induced in 60 rats by performing a duodenesophagostomy. The study group received daily intraperitoneal injections of a proton pump inhibitor for 6 months and the control group received an equivalent injection of saline. Rats were examined at death for macroscopic tumor, dysplasia, adenocystic changes, papillomatosis, and adenocarcinoma. Five out of 19 rats in the study group and three out of 20 rats in the control group developed dysplastic/adenocarcinomatous changes. Ten of the rats in the study group died before the end of the study, as opposed to one in the control group (this is not statistically significant). There was no difference in the number of cancers that developed in the two groups. However, there was an insignificant trend to earlier appearance of detectable disease in the study group.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11422300&dopt=Abstract
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Dig Dis Sci. 1986 Jul;31(7):753-9.
Effect of antisecretory agents and vagotomy on healing of "chronic" cysteamine-induced duodenal ulcers in rats.
Poulsen SS, Raaberg L, Therkelsen K, Skov Olsen P, Kirkegaard P.
Penetrated cysteamine-induced duodenal ulcers in rats have a very prolonged course of healing. In this study, it was investigated how much the healing of these ulcers is accelerated by some treatments. The treatments included omeprazole, cimetidine, and truncal vagotomy. In addition, the effect of omeprazole and cimetidine on gastric acid secretion was investigated in chronic gastric fistula rats. After 25 days of treatment, significantly more rats in the treated groups had healed ulcers than in the control group. There was little further improvement up to 100 days of treatment, and the difference between treated and untreated groups decreased. The morphology of healing ulcers in treated and untreated rats was also compared. In controls, there was a simultaneous regeneration of mucosa and the submucosal Brunner's glands from the edges of the ulcer, the slow proliferation rate of the latter probably being decisive for the prolonged healing. In the treated rats, the mucosa first regenerated with formation of crypts and low villi and subsequently, the Brunner's glands were formed by proliferation from the bottom of the crypts.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3720471&dopt=Abstract
note: kwd match prilosec online literature
Presse Med. 1989 Dec 2;18(40):1970-3.
[Angina-like chest pain of esophageal origin]
[Article in French]
Bory M, Dupin B.
Service de Cardiologie, Hopital de la Timone, Marseille.
Chest pain of oesophageal origin closely resembles chest pain of coronary origin, and the distinction between these two sources of pain is crucial to give the patients a precise prognosis and to use the appropriate therapeutic approach. Once the coronary origin has formally been excluded, the oesophageal origin can be confirmed by several examinations of varying sensitivity and specificity. To date, prolonged oesophageal manometric and pH recordings give highly reliable results as they establish a cause-effect relationship between pain and the phenomena recorded. Besides, these methods have refined the therapeutic approach since they also inform on the mechanisms of oesophageal pain.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2531883&dopt=Abstract
note: kwd match prilosec online literature
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