Drugs online research references
J Chromatogr. 1992 May 20;577(1):117-22.
Determination of lansoprazole and its metabolites in plasma by high-performance liquid chromatography using a loop column.
Landes BD, Miscoria G, Flouvat B.
Laboratoire de Toxicologie et de Pharmacocinetique, Hopital Ambroise Pare, Boulogne Billancourt, France.
A high-performance liquid chromatographic method for the simultaneous determination of lansoprazole, a new proton pump inhibitor, and its metabolites in human plasma is described. Lansoprazole, its metabolites and an internal standard were extracted with tert.-butyl methyl ether. Samples were injected using an automatic injector via a loop column, and separation was obtained using a reversed-phase column under isocratic conditions. The absorbance was monitored at 285 and 303 nm. The quantification limit was 2 ng/ml for lansoprazole and 3 or 5 ng/ml for the metabolites. No endogenous compounds were found to interfere. The mean overall recovery was between 75 and 95% for lansoprazole and its metabolites. This method is suitable for pharmacokinetic studies.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1400730&dopt=Abstract
note: kwd match prilosec online literature
J Chromatogr B Biomed Appl. 1995 Jun 9;668(1):182-6.
Determination of lansoprazole and five metabolites in plasma by high-performance liquid chromatography.
Karol MD, Granneman GR, Alexander K.
Drug Metabolism Department, Abbott Laboratories, Abbott Park, IL 60064-3500, USA.
A high-performance liquid chromatographic method for the determination of lansoprazole, a new proton-pump inhibitor, and five of its metabolites in human plasma is described. Lansoprazole, its metabolites, and internal standard (omeprazole) were extracted into diethyl ether-methylene chloride and separation was obtained using a reversed-phase column under isocratic conditions. The method features monochromatic ultraviolet detection at 285 nm, and single extraction, single evaporation sample handling. The lower limit of quantitation, based on standards with acceptable coefficients of variation, was 10 ng/ml for all compounds. No endogenous compounds were found to interfere. This method has been demonstrated to be suitable for pharmacokinetic studies in humans.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7550976&dopt=Abstract
note: kwd match prilosec online literature
Eur J Drug Metab Pharmacokinet. 1998 Apr-Jun;23(2):329-32.
Determination of lansoprazole in biological fluids and pharmaceutical dosage by HPLC.
Avgerinos A, Karidas T, Potsides C, Axarlis S.
Military Pharmaceutical Laboratories, Athens, Greece.
A simple and rapid (extractionless) high-performance liquid chromatographic method with UV detection at 230 nm was developed for the determination of lansoprazole in biological fluids and pharmaceutical dosage. Niflumic acid was added as internal standard. The separation was performed at ambient temperature on a C18 Spherisorb column with acetonitrile + 0.1 M sodium acetate (40:60, v/v, pH 7) as mobile phase. The retention time was 5.2 min for niflumic acid and 6.7 min for lansoprazole. The detection limit was 20 ng/ml using a 100 microl loop. The method was successfully applied to a pharmacokinetic study of lansoprazole in humans.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9725501&dopt=Abstract
note: kwd match prilosec online literature
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