Drugs online research references
Hepatology. 1992 Jun;15(6):1031-5.
Bleeding from staple line erosion after esophageal transection: effect of omeprazole.
Kaye GL, McCormick PA, Siringo S, Hobbs KE, McIntyre N, Burroughs AK.
Hepatobiliary and Liver Transplantation Unit, Royal Free Hospital and School of Medicine, Hampstead, London, United Kingdom.
Esophageal staple transection effectively controls acute variceal bleeding, but up to 50% of these patients will have recurrent upper gastrointestinal bleeding. In our experience, most of these bleeding episodes are caused by total or partial circumferential ulceration at the level of the staple transection: staple line erosion. It caused rebleeding in 29 (40%) of our patients. Whereas the pathogenesis of this lesion is unknown, acid reflux is a consequence of transection surgery. Assuming that staple line erosion could be healed by acid suppression therapy, thereby preventing recurrent bleeding, an acid suppression regimen was evaluated prospectively in 24 patients. Only six (25%) healed with daily standard (300 mg) or high-dose (1,200 mg) ranitidine combined with sucralfate (4 gm). The remaining 18 (75%) healed after omeprazole administration (40 mg/day) for 1 mo. Maintenance ranitidine alone (300 mg/day) was introduced, but 11 (48%) had relapse of erosions. All 11 healed with omeprazole (40 mg/day) for 2 mo, but again on maintenance ranitidine, 10 relapsed. All healed with further omeprazole and healing persisted with long-term administration (20 mg/day). Fifteen rebleeding episodes occurred in eight patients on maintenance ranitidine. Whereas relapse of staple line erosions did occur in the absence of rebleeding, all rebleeding episodes were associated with the relapse of staple line erosion. Omeprazole is more effective than ranitidine alone and combined with sucralfate in healing staple line erosion. Omeprazole prevents rebleeding, which may enhance the long-term benefits of staple transection for acute variceal bleeding.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1592340&dopt=Abstract
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Methods Find Exp Clin Pharmacol. 1990 Nov;12(9):613-8.
Use of a cannula insert in erratic emptying Heidenhain pouch dogs: effect of single and cumulative doses of omeprazole.
Ghelani A, Radziwonik H.
Dept. of Pharmacology, Research and Development Laboratories, Loughborough, UK.
A novel cannula insert was used to correct erratic emptying in Heidenhain pouch dogs. The insert restored the recovery of histamine or pentagastrin stimulated gastric acid secretion to that obtained from normal emptying pouch dogs, probably by displacing obstructing tissue within the pouch. Use of the insert did not cause any discomfort to the animals, nor did it alter basal secretion. There was no significant difference between the antisecretory activity of single doses of omeprazole in erratic emptying animals fitted with the insert (ED50 = 0.21 mumol/kg) and in dogs with a normal pouch (ED(50) = 0.13 mumol/kg). Use of the insert achieved an earlier steady secretory response which allowed cumulative dosing to be performed in each animal. There was no significant difference between the effect of cumulative (ED50 = 0.24 mumol/kg) and single doses of omeprazole in erratic emptying dogs. Although there was a significant difference between cumulative dosing in erratic emptiers and single dosing in normal animals it should still be possible to use erratic emptiers with the insert for screening purposes.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2084455&dopt=Abstract
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Int J Clin Pract. 1997 Nov-Dec;51(8):516-7.
Does smoking influence the eradication of Helicobacter pylori and duodenal ulcer healing with different regimens?
Kadayifci A, Simsek H.
Department of Internal Medicine, Hacettepe University, Ankara, Turkey.
To determine the effect of smoking on Helicobacter pylori eradication and ulcer healing, we investigated 232 patients with H. pylori-positive duodenal ulcer. Patients were given one of seven different treatment protocols and divided into three groups according to smoking habits. Group 1 (n = 128) consisted of non-smokers, group 2 (n = 65) of mild smokers (5-20 cigarettes/day) and group 3 (n = 39) of heavy smokers (> 20/day). The eradication of H. pylori and ulcer healing rate was controlled eight weeks later after ceasing the therapy. The overall eradication rate was 66% in all patients and 68%, 66%, 59% in each group, respectively. The eradication rates showed no statistical difference between groups. Complete ulcer healing was achieved in 84% of all patients and ulcer healing rate between groups did not show any significance (85%, 83% and 82% respectively). These results suggest that smoking status does not influence the eradication of H. pylori and duodenal ulcer healing rates at eight weeks in patients on different treatment schedules.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9536607&dopt=Abstract
note: kwd match prilosec online literature
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