Drugs online research references
J Pediatr. 1979 Jul;95(1):131-5.
Use of the serum bactericidal titer to assess the adequacy of oral antibiotic therapy in the treatment of acute hematogenous osteomyelitis.
Prober CG, Yeager AS.
Serum bactericidal titers against Staphylococcus aureus were measured in 63 children who were receiving mafcillin or methicillin intravenously, or dicloxacillin, penicillin, or cephalexin orally. The SBTs obtained following unit does of 25 mg/kg of dicloxacillin, 35 mg/kg of penicillin, or 25 mg/kg of cephalexin with probenecid were comparable to those seen following intravenous doses of 40 mg/kg nafcillin or methicillin. Twenty-two children with acute hematogenous osteomyelitis proven or presumed to be due to S. aureus were treated intravenously until point tenderness and fever had resolved, and then with oral therapy. The mean duration of intravenous therapy was 14 days. Oral doses were adjusted so that a peak SBT of greater than or equal to 1:16 and a trough SBT of greater than or equal to 1:2 were obtained in most children. No recurrences occurred. The SBT proved to be a practical means of assessing the adequacy of oral therapy in children with infections due to S. aureus.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=113517&dopt=Abstract
Age Ageing. 1978 Aug;7(3):182-8.
Antibiotic-associated colitis: a retrospective study of fifteen cases.
Roddis MJ.
Fifteen cases of antibiotic-associated colitis were reviewed in a retrospective study of all the cases seen in a general hospital in the period 1970--7. Nine of these cases were diagnosed as pseudomembranous colitis. This was found mostly in patients over 65 years of age, where it resulted in severe illness with 70% mortality. The antibiotics involved included ampicillin, penicillin, clindamycin, erythromycin and co-trimoxazole (Septrin). Pseudomembranous colitis is a serious hazard in the elderly and may be caused by a wide range of antibiotics in common use.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=101026&dopt=Abstract
Biosens Bioelectron. 2001 Jun;16(4-5):277-86.
A novel microphysiometer based on MLAPS for drugs screening.
Yicong W, Ping W, Xuesong Y, Qingtao Z, Rong L, Weimin Y, Xiaoxiang Z.
Biosensor National Special Lab., Dept. of Biomedical Engineering, Zhejiang University, Hangzhou, Zhejiang, 310027, People's Republic of China.
This paper presents a novel microphysiometer for simultaneous measurements of several extracellular ions concentrations in living cells based on MLAPS (multi-light addressable potentiometric sensor). In the microphysiometer, different sensitive membranes are illuminated in parallel with n light sources at different frequencies, the response amplitudes of each frequency component can be measured on-line by parallel processing algorithm. By the experiments, we can analyze the relations of the extracellular environmental H(+), Na(+), K(+), Ca(2+) under the effects of western medicines (dilantin, phenobarbital sodium, penicillin sodium) and Chinese drugs (scutellaria, medlar, hemlock parsley), and estimate the effects of several drugs. As the novel microphysiometer works under regular cell culture conditions, cells can be repeatedly simulated with drugs to complete dose-response curve within a few hours. With the detection of a general parameter (extruded protons and ions), the system can be used to monitor the real-time process of the cells' metabolism, observe the functional responses of different kinds of membrane-bound receptors, evaluate the drugs.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11390215&dopt=Abstract
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