Drugs online research references
Antibiot Med Biotekhnol. 1985 Feb;30(2):99-101.
[Spectrophotometric method of determining phenoxymethylpenicillin in the air]
[Article in Russian]
Churagulova NK.
A modified spectrophotometric method is recommended for the control of the air condition at pharmaceutical plants manufacturing phenoxymethylpenicillin and its dosage forms. The method is based on measuring absorption of the mixture solutions at two (258 and 268) and three (253, 268 and 261) wave lengths. The limit of the measuring in the solution volume is 0.015 mg. The air samples are collected on filters AFA-VP-20 or AFA-KHP-20 at an aspiration rate of 15-20 l/min and then the antibiotic is extracted in a 0.04 per cent solution of sodium bicarbonate.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3923919&dopt=Abstract
Appl Environ Microbiol. 1985 May;49(5):1084-9.
Molecular cloning of Bacillus sphaericus penicillin V amidase gene and its expression in Escherichia coli and Bacillus subtilis.
Olsson A, Hagstrom T, Nilsson B, Uhlen M, Gatenbeck S.
The Bacillus sphaericus gene coding for penicillin V amidase, which catalyzes the hydrolysis of penicillin V to yield 6-aminopenicillanic acid and phenoxyacetic acid, has been isolated by molecular cloning in Escherichia coli. The gene is contained within a 2.2-kilobase HindIII-PstI fragment and is expressed when transferred into E. coli and Bacillus subtilis. The expression in B. subtilis carrying the recombinant plasmid is approximately two times higher than in the original B. sphaericus strain. A comparison of the purified enzyme from B. sphaericus and the expressed gene product in E. coli minicells suggests that the native enzyme consists of four identical subunits, each with a molecular weight of 35,000.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3923928&dopt=Abstract
Br J Clin Pharmacol. 1985 May;19(5):657-68.
Comparative pharmacodynamics and clinical pharmacokinetics of phenoxymethylpenicillin and pheneticillin.
Overbosch D, Mattie H, van Furth R.
In this study the antimicrobial effects of phenoxymethylpenicillin (PM) and pheneticillin (PE) in vitro and in an experimental animal infection model were compared as well as the pharmacokinetic properties of both drugs in patients. For the inhibitory effect of PM on short-term (3 h) growth of S. aureus in vitro, this drug was 2.13 times more potent than PE. The protein binding of both drugs was similar (78-80%). The potency ratio of PM to PE against S. aureus in an experimental mouse-thigh infection was only 1.25 to 1. This is explained by the difference in the AUC after subcutaneous administration of PM (0.47 mg 1(-1) h) and PE (0.92 mg 1(-1) h). The plasma clearance after intravenous administration of PM was 476.4 ml/min and that of PE was 295.1 ml/min; the plasma clearance of both drugs was strongly correlated with the creatinine clearance. The volume of distribution in the steady state of PM was 35.41 and that of PE 22.51. In 10 patients, the absorption after oral administration of PM as the acid was 48% and that of the potassium salt of PE was 86% of the dose. From the present results it can be concluded that a difference in effectiveness of different formulations of PM and PE would depend entirely on differences in absorption.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3924086&dopt=Abstract
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