Drugs online research references
J Antimicrob Chemother. 1985 Jan;15 Suppl A:233-9.
Bactericidal activity of phenoxymethylpenicillin in an in-vitro model simulating tissue kinetics.
Sous H, Hirsch I.
The antibacterial efficacy of phenoxymethylpenicillin (Pen-V-K) against strains of Staphylococcus aureus was assessed in an in-vitro kinetic model. Simulation was based on human serum levels and tissue water curves obtained after a single oral dose of 392.2 mg of the drug. Differences in bacterial elimination kinetics were noted depending upon the type of curve (serum or tissue water) being simulated.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3920182&dopt=Abstract
N Engl J Med. 1985 May 9;312(19):1229-32.
Penicillin allergy and desensitization in serious infections during pregnancy.
Wendel GD Jr, Stark BJ, Jamison RB, Molina RD, Sullivan TJ.
Penicillin allergy presents a major obstacle to the successful management of some antepartum infections. We studied 15 pregnant women with histories of penicillin allergy confirmed by positive immediate wheal-and-flare skin tests. Thirteen had syphilis, one listeria sepsis, and one Streptococcus viridans endocarditis. Each patient was desensitized over four to six hours by oral administration of increasing doses of penicillin V. At the completion of the procedure, full-dose parenteral therapy with penicillin G or ampicillin was instituted. No extracutaneous reactions were detected. Five of the subjects (33 per cent) experienced pruritus (three) or urticaria (two), but no interruption of desensitization or therapy was necessary. All clinically apparent maternal infections were cured. The pregnancy complicated by listeriosis aborted in the first trimester. The 11 neonates delivered to date are normal. These results indicate that oral desensitization is an acceptably safe approach to therapy in pregnant women who are allergic to penicillin and have infections that require beta-lactam drugs.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3921835&dopt=Abstract
J Pharmacol Methods. 1985 Jun;13(3):275-80.
Application of Azure C for the extractive spectrophotometric determination of microgram amounts of penicillin.
Gowda AT, Gowda NM, Gowda HS, Rangappa KS.
A simple, accurate, and rapid method for the quantitative determination of penicillin is proposed. The method is based on the formation of a blue penicillin-Azure-C ion-pair that can be extracted into chloroform in phosphate-citric acid buffer. The molar absorptivities for sodium penicillin G and potassium penicillin V at 635 nm were 5.46 X 10(3) and 2.19 X 10(4) l/mol/cm, respectively. Beer's law was valid over the concentration range of 4-80 micrograms/ml for sodium penicillin G and 3-55 micrograms/ml for potassium penicillin v. Maximum absorbance was obtained almost instantaneously and was stable for several days. The method was successfully applied to pharmaceutical preparations.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3923272&dopt=Abstract
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