Drugs online research references
Urology. 1988 Aug;32(2 Suppl):22-7.
Protocol for treatment of typical urinary tract infection: criteria for antimicrobial selection.
Parsons CL.
Department of Surgery, University of California School of Medicine, San Diego.
Criteria for selecting an appropriate drug for treatment of urinary tract infection are based on therapeutic goals. A major criterion is to choose an antimicrobial that will not affect the patient's fecal and vaginal flora. Low cost is another important criterion. It is unnecessary to select an expensive antimicrobial when highly effective agents are available at low cost. High urinary concentration is the third goal of therapy and a major criterion for selecting an appropriate drug. To apply these selection criteria in clinical practice, use a criteria-based classification. Choose the agent highest on the following lists for which the patient shows no sensitivity: Class I, nitrofurantoin macrocrystals and penicillin VK; Class II, carbenicillin; Class III, amoxicillin; Class IV, trimethoprim-sulfamethoxazole and cephalosporins; Class V, ampicillin, tetracycline, norfloxacin.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3407056&dopt=Abstract
Pharmacotherapy. 1987;7(4):125-9.
Increased frequency of doxycycline side effects.
Bryant SG, Fisher S, Kluge RM.
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77550.
As part of a study investigating new methods of detecting adverse drug reactions, adult outpatients receiving new prescriptions for 1 of 4 antibiotics (doxycycline, penicillin VK, ampicillin, or tetracycline) were assigned to 1 of 2 methods of monitoring adverse drug reactions. Data were collected from a total of 457 staff-initiated interviews and from 1467 patients who were asked to telephone to report possible adverse effects. Doxycycline is considered by authoritative sources to be generally comparable in side effects to other tetracyclines and penicillins, with the exception that it increases photosensitivity. Results from both monitoring methods consistently indicated at least a 3-fold higher frequency of nausea or vomiting with doxycycline relative to the other antibiotics. Complaints of skin rash also were at least 4 times more frequent with doxycycline, depending on the particular sample.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3684731&dopt=Abstract
JAMA. 1979 Apr 27;241(17):1801-6.
Single-antibiotic therapy for streptococcal endocarditis.
Karchmer AW, Moellering RC Jr, Maki DG, Swartz MN.
Ninety-nine patients treated with penicillin G potassium, cephalothin sodium, or vancomycin hydrochloride were studied to evaluate single-drug therapy for nonenterococcal streptococcal endocarditis. Eighty-six patients survived; of these, 66 received penicillin alone. The maximum serum bactericidal titer obtained at the expected nadir of serum antibiotic concentration was 1:8 or greater in 70 (95%) of the 74 patients studied. No relapse occurred among the 66 patients treated wih penicillin. Only one patient experienced a relapse that occurred following therapy with suboptimal doses of vancomycin. Distinct second episodes of endocarditis occurred in five patients. While 13 patients died, none died of intractable infection. The treatment of endocarditis due to penicillin-susceptible streptococci with high-dose parenteral penicillin or a bactericidal penicillin substitute for four weeks or longer results in bacteriologic cure rates comparable with those achieved with combined penicillin-streptomycin regimens.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=107335&dopt=Abstract
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