Drugs online research references
Eur J Clin Microbiol Infect Dis. 1988 Apr;7(2):172-4.
Bacteriological and serological aspects of group A streptococcal pharyngotonsillitis caused by group A streptococci.
Stromberg A, Schwan A, Cars O.
Department of Infectious Diseases, Uppsala University, Sweden.
Several bacteriological and serological variables were studied in connection with a clinical treatment trial in 212 patients with group A streptococcal pharyngotonsillitis. Anaerobic incubation was not superior to incubation in 5% CO2 in air for the detection of group A streptococci. Saliva cultures were inferior to conventional throat cultures in detecting group A streptococci. No strains from patients with recurrences were found to be tolerant to penicillin. In several patients (all asymptomatic), group C and G streptococci were found in follow-up cultures. Group A streptococci serology was more often positive after two months than after one month, also in patients without recurrence.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3134205&dopt=Abstract
J Antimicrob Chemother. 1988 Jun;21 Suppl D:29-32.
Effects of two erythromycins, doxycycline and phenoxymethylpenicillin on human leucocyte chemotaxis in vitro.
Aho P, Mannisto PT.
Research Centre, Orion Pharmaceutica, Espoo, Finland.
The effect of erythromycin, doxycycline and phenoxymethylpenicillin on human polymorphonuclear leucocyte (PMNL) chemotaxis was studied in vitro with Boyden's filter technique. Both erythromycin base and 2'-acetyl erythromycin stearate increased the PMNL chemotaxis significantly at concentrations greater than or equal to 50 microM, 2'-acetyl erythromycin stearate also at concentrations of 2.5-5 microM. Phenoxymethyl-penicillin reduced migration at 500 microM but lower concentrations had no significant effect. Doxycycline prevented migration significantly at concentrations greater than or equal to 50 microM.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3134323&dopt=Abstract
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1979 Feb 8;209(4):249-55.
[Aqueous-and serum levels of cephalexin and penicillin V after oral application in man (author's transl)]
[Article in German]
Engels T, Ehrhorn J, Bleckmann H.
This clinical study implies orally administered cephalexin and penicillin V as agents with effective aqueous homor penetration in noninfected human eyes. Aqueous humor concentration of cephalexin increases up to 15% of the serum level 2 h after application. Administration of 1 g or 2 g cephalexin revealed no significant difference in aqueous humor concentration. So penetration of blood-aqueous-humor barrier can be regarded as a saturation process. Individual results of 92 cephalexin determinations are variant and not related to body weight or age of the patients.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=106743&dopt=Abstract
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