Drugs online research references
J Antimicrob Chemother. 1986 Jun;17(6):767-74.
Comparison of the effect of phenoxymethylpenicillin, cloxacillin, and flucloxacillin on Staphylococcus aureus phagocytosed by human monocytes.
van den Broek PJ, Buys LF, Mattie H, van Furth R.
The antibacterial effect of phenoxymethylpenicillin, cloxacillin, and flucloxacillin on pre-opsonized Staphylococcus aureus ingested by human monocytes and on preopsonized S. aureus in suspension was compared. The antibiotics were 1.7-3 times more effective against intracellular S. aureus than against S. aureus in suspension. No influence of acid stability or lipid solubility of the drugs on the antibacterial effect against intracellular S. aureus was demonstrated.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3090009&dopt=Abstract
Trop Geogr Med. 1986 Jun;38(2):119-22.
Compliance with penicillin prophylaxis by children with impaired splenic function.
Babiker MA.
42 children with impaired splenic function were followed-up for 8 months for compliance with penicillin prophylaxis. Parents of 24 children (group A) chose a twice daily oral while parents of 18 children (group B) chose a 3-weekly injection regimen. The penicillin intake was checked by the presence of antibacterial activity in urine obtained at clinic visits. The clinics attendance rate for both groups was 92.7% and 94.9% respectively. For group A 44% of urines tested were positive indicating poor compliance with oral medication over the previous 5 to 16 hours. The educational level of parents and age and sex of children did not influence compliance. It seems safer, therefore, to use an intramuscular regimen rather than rely on oral prophylaxis in children with impaired splenic function.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3090751&dopt=Abstract
Eur J Clin Microbiol. 1986 Aug;5(4):399-404.
Emergence of beta-lactamase producing anaerobic bacteria in the tonsils during penicillin treatment.
Tuner K, Nord CE.
The emergence of beta-lactamase producing bacteria in the microflora in the oropharyngeal cavity was studied in ten healthy volunteers treated with 1 g phenoxymethylpenicillin b.i.d. for ten days. Beta-lactamase activity in saliva was also investigated. A significant increase in the number of beta-lactamase producing strains of Bacteroides species and Fusobacterium nucleatum was observed. One beta-lactamase producing Staphylococcus aureus strain was recovered in one of the volunteers before the penicillin administration started and three Staphylococcus aureus strains produced beta-lactamase after ten days of antibiotic treatment. Beta-lactamase-production in Haemophilus influenzae, Haemophilus parainfluenzae or Branhamella catarrhalis was not observed before, during or after the antibiotic treatment. Beta-lactamase activity was noted in the broth cultures from one volunteer colonized with a beta-lactamase producing Escherichia coli strain. Beta-lactamase activity in saliva was observed in all volunteers, the activity increasing significantly in parallel to the increase of beta-lactamase producing bacterial strains. Beta-lactamase activity in saliva was completely inhibited in vitro by clavulanic acid and p-chloromercurbenzoate and about 70-80 per cent of the activity was inhibited by cefoxitin. The increase of beta-lactamase producing bacteria in the oropharynx as a consequence of penicillin treatment raises doubt as to whether penicillin is the drug of choice in the treatment of tonsillitis caused by group A streptococci when previous treatment has failed.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3093222&dopt=Abstract
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