Drugs online research references
Microbiol Immunol. 1989;33(1):69-74.
Penicillin amidohydrolases in fungal autolysis.
Alfonso C, Cribeiro L, Reyes F.
Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain.
The production of penicillin G and penicillin V amidohydrolases or acylases (E.C.3.5.1.11) was studied during the autolysis of filamentous fungi in a mineral medium, and in the same medium with phenoxyacetic acid as inducer. In all the studied fungi, enzymes showing penicillin G and penicillin V amidohydrolase activities were found. Generally, an increase of these activities during fungal autolysis was observed. The presence of phenoxyacetic acid in the medium did not increase these activities. The activities found in the culture fluids were generally higher than that found in the mycelial extracts. Under these conditions, beta-lactamases (penicillinases) were not found. The fungi Alternaria alternata, Fusarium culmorum, Penicillium oxalicum, and the species Penicillium 222 were chosen to study penicillin G and penicillin V acylases. The enzymes were precipitated with tannic acid from the culture fluid of their autolyzed cultures. Some kinetic constants of these activities were determined.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2499747&dopt=Abstract
Padiatr Padol. 1979;14(1):69-74.
[Bioavailability of orally administered antibiotics: influences of food on resorption (author's transl)]
[Article in German]
Guggenbichler JP, Kienel G.
After the administration of a liquid suspension of Penicillin V-K, Epicillin, Cephalexin, Ampicillin, Pivampicillin and Amoxycillin on fasting and not fasting children, plasma levels and urine excretion of antibiotics were determined. A standard meal influences in Penicillin V-K and Ampicillin not only the maximum plasma levels, but also the absorbed amount of the drug. In Epicillin, Pivampicillin and Cephalexin we were not able to detect an influence of food on absorption. Amoxycillin doesn't seem to be impaired by food. However, the considerable individual differences could have its reasons in a number of other factors presently investigated.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=105335&dopt=Abstract
Pathol Biol (Paris). 1989 Apr;37(4):273-5.
[Comparative study of the penetration of penicillin V, amoxicillin, cefaclor and josamycin in the tonsils]
[Article in French]
Bizet C, Pangon B, Moisy N, Bizet J, Bure A, Gehanno P.
Laboratoire Central de Bacteriologie, Hopital Claude-Bernard, Paris, France.
Fourty patients undergoing tonsillectomy for recurrent tonsillitis were administered penicillin V, amoxicillin, cefaclor or josamycin. Antibiotic concentrations in serum and tonsillar tissues were determined by microbiological assay. Cefaclor demonstrated a superior diffusion than penicillin V and amoxicillin, but nevertheless inferior to that of josamycin.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2499865&dopt=Abstract
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