Drugs online research references
Scand J Infect Dis. 1991;23(3):309-13.
In vivo attachment of group A streptococci to tonsillar epithelium during acute tonsillitis.
Stenfors LE, Raisanen S, Rantala I.
Department of Otolaryngology, University of Tromso, Norway.
The attachment of group A beta-hemolytic streptococci (GABHS) to the tonsillar epithelium during current acute tonsillitis (AT) was studied by means of fluorescence microscopy and electron microscopy in 5 patients. Conventional cultures from the tonsils showed massive growth of GABHS and tonsillar epithelial cells were heavily infested with GABHS, which proved positive for FITC-labelled antibodies against beta-hemolytic streptococci. The bacteria were firmly attached to the epithelial cell membranes by cell projections, which grasped the microorganisms from various directions. A 24 h course of oral treatment with phenoxymethylpenicillin radically affected bacterial adherence to the epithelial cells.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1909050&dopt=Abstract
Acta Obstet Gynecol Scand. 1991;70(2):129-31.
Excretion of phenoxymethylpenicillin in the vaginal fluid of hysterectomized women.
Sjoberg I, Hakansson S.
Department of Obstetrics and Gynecology, Umea University Hospital, Sweden.
The excretion of phenoxymethylpenicillin in vaginal fluid was determined in 19 hysterectomized women, 8 totally and 11 subtotally operated. Phenoxymethylpenicillin was found in the vaginal fluid in high concentrations in both groups of women and it was concluded that the substance penetrates the vaginal wall. Concentrations were significantly higher in the most distal part of the vagina. The possible mechanisms for this phenomenon are discussed.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1909080&dopt=Abstract
Acta Otolaryngol. 1991;111(3):562-8.
In vivo attachment of beta-haemolytic streptococci to tonsillar epithelial cells in health and disease.
Stenfors LE, Raisanen S.
Department of Otolaryngology, University of Tromso, Norway.
In vivo attachment of beta-haemolytic streptococci Group A (GABHS) to the epithelial cells of the palatine tonsils was determined in 10 patients with current acute tonsillitis (AT-group) and in 10 healthy carriers of GABHS (C-group) according to a method described. Standard bacterial culture revealed growth of GABHS in both groups. In the AT-group, massive attachment of streptococcal chains to the tonsillar epithelium was noted. These chains proved positive for FITC-labelled antibodies against beta-haemolytic streptococci, and were only occasionally found in the C-group. The overall bacterial attachment was significantly greater in the AT-group than in the C-group (p less than 0.001). Phenoxymethylpenicillin treatment caused a dramatic decrease in the number of the attached GABHS bacteria within 24 h. Two weeks after completion of the penicillin treatment one individual in each group was still culture-positive for GABHS.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1909488&dopt=Abstract
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