Drugs online research references
Antibiotiki. 1983 Nov;28(11):818-22.
[Purification of antibiotics by ultrafiltration through semi-permeable membranes]
[Article in Russian]
Ustiuzhanina IIu, Ivanova MV, Stremovskii LL.
The process of purification of benzylpenicillin, penicillin V and erythromycin solutions with the use of semi-permeable membranes was studied. Practically complete separation of high-molecular admixtures and microbial colonies and separation of significant amounts of the colored compounds were shown to be possible. The purification process may be used effectively at the early stages of antibiotic production.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6418062&dopt=Abstract
jk.uni.linz.ac.at
A method for the determination of penicillin V together with its impurities and by-products formed during biosynthesis, using capillary electrophoresis (CE) with UV and electrospray-mass spectrometric (ESI-MS) detection is presented. Aqueous and nonaqueous electrolytes containing 20 mM ammonium acetate were investigated to determine their suitability for the separation of these analytes. These carrier electrolytes were optimized with respect to the pH and the solvent/s used (water, methanol, acetonitrile, ethanol and isopropanol) and it was shown that although the nonaqueous electrolytes offered unique separation selectivities, the best results in terms of selectivity and sensitivity were obtained for the aqueous system. Finally, the applicability of this method for the analysis of a mixture representative of a real fermentation broth was demonstrated using an aqueous carrier electrolyte with both UV and ESI-MS detection.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11870741&dopt=Abstract
J Int Med Res. 1983;11(6):380-4.
Absorption of phenoxymethylpenicillin from mixtures and tablets in healthy volunteers.
Josefsson K, Magni L.
The absorption of the potassium, calcium and benzathine salts of phenoxymethylpenicillin, given as mixtures, was investigated in twelve healthy volunteers. The potassium salt gave the fastest and highest serum peak levels. Also the relative bioavailability of the potassium salt was greatest, as indicated by the areas under the serum concentration/time curves (AUC). In a second study with twelve other volunteers, the absorption of the mixtures and tablets of the potassium salt was studied. The peak serum levels and AUC were comparable after these preparations. The results in our two studies indicate that, from a pharmacokinetic point of view, the potassium salt of phenoxymethylpenicillin in mixtures should be preferred in clinical practice. It also appears that the absorption of phenoxymethylpenicillin from the tablets and mixtures of the potassium salt is comparable, giving the same relative bioavailability.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6418583&dopt=Abstract
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