Drugs online research references
Pediatr Pharmacol (New York). 1983;3(1):37-41.
Comparative pharmacological evaluation of oral benzathine penicillin G and phenoxymethyl penicillin potassium in children.
Fujita K, Sakata H, Murono K, Hasegawa H, Takimoto M, Yoshioka H.
Serum penicillin concentrations and urine excretion rates of oral benzathine penicillin G and phenoxymethyl penicillin potassium were evaluated in children. Mean peak serum concentration of 0.134 microgram/ml of benzathine penicillin G and 1.018 microgram/ml of phenoxymethyl penicillin potassium were measured at 125 and 35 min. The mean half-life times were 1.36 and 0.74 hr, and for area under the curve, the values were 0.34 and 1.68 microgram . hr/ml for benzathine penicillin G and phenoxymethyl penicillin potassium groups, respectively. Phenoxymethyl penicillin potassium had more reliable pharmacokinetic properties and would be the preferred forms of oral penicillin. However, all patients receiving penicillin G had penicillinemia, which was enough to inhibit most strains of Streptococcus pyogenes for a longer period than phenoxymethyl penicillin potassium. Palatability of phenoxymethyl penicillin is less than for benzathine penicillin G; the latter may be used for children in whom compliance may be a problem.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6417621&dopt=Abstract
Scand J Infect Dis Suppl. 1983;39:83-5.
Betalactamase-producing microorganisms in recurrent tonsillitis.
Tuner K, Nord CE.
In 73% of 167 patients with recurrent tonsillitis, colonization with betalactamase-producing microorganisms was found. Betastreptococci group A were recovered in 6% of the patients and group C and G streptococci in 23%. Other microorganisms found were Staphylococcus aureus in 42%, Haemophilus species in 52%, bacteroides species in 80% and fusobacteria in 40%. Ninety-eight per cent of Staph. aureus, 60% of bacteroides species and 10% of fusobacteria were betalactamase-producing. Phenoxymethylpenicillin (1 g twice a day for ten days) diminished 50% of group A, C and G streptococci. No other microorganisms were affected by this antibiotic. Clindamycin (0.15 g four times a day for ten days) eradicated Staph. aureus, group A, C and G streptococci, bacteroides and fusobacteria. Haemophilus species were not affected by clindamycin. Tinidazole (1 g once a day for 10 days) diminished bacteroides and fusobacteria. Aerobic microorganisms, Staph. aureus, streptococci and Haemophilus, were not affected by tinidazole.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6417772&dopt=Abstract
Acta Otolaryngol. 1984 Jan-Feb;97(1-2):117-26.
The nasopharyngeal microflora of otitis-prone children, with emphasis on H. influenzae.
Freijd A, Bygdeman S, Rynnel-Dagoo B.
The nasopharyngeal microflora was monitored during a prospective study of 52 otitis-prone children and 33 age-matched controls up to the age of 30 months. The relation between nasopharyngeal culture results and corresponding otoscopic findings was investigated. In contrast to pneumococci, the rate of H. influenzae isolation was correlated to the degree of otologic disease, thus it was found more often in connection with AOM than with a normal otologic status, with OME in an intermediate position. Also in contrast to pneumococci, in children with AOM, H. influenzae was commoner in the otitis-prone group than in the control group. H. influenzae biotype II was found in 77% in association with AOM in the control group. In the otitis-prone group the difference in frequency of biotypes I, II and III causing AOM were less pronounced. Turnover of H. influenzae strains as judged by change in biotype was found to occur more often in connection with treatments with penicillin-V than treatments with amoxicillin.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6417970&dopt=Abstract
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