Drugs online research references
Acta Otolaryngol. 1976 May-Jun;81(5-6):475-83.
The antibacterial effect of antibiotics in treatment of maxillary sinusitis.
Eneroth CM, Lundberg C.
The antibacterial effect of antibiotic treatment in maxillary sinusitis has been assessed by studying the elimination of bacteria from the maxillary sinus during treatment with penicillin and tetracycline. As adequate antibiotic concentrations are the prerequisite for maximal antibacterial effect, the antibiotic concentrations were controlled. The antibiotic concentrations were determined in maxillary sinus secretions and/or mucosas of 113 patients with maxillary sinusitis, treated with single or repeated doses of penicillin or tetracycline, or the two antibiotics in combination. In 30 patients treated with either penicillin or tetracycline, the bacterial growth in sinus secretion was controlled before and after treatment. It was established that ordinary clinical doses of penicillin and tetracycline may, although not invariably, result in antibiotic concentrations in sinus secretion and sinus mucosa than can be regarded as adequate for treatment, i.e. for penicillin greater than or equal to 0.25 mug/ml and for tetracycline greater than or equal to 1.0 mug/ml. The necessity of achieving adequate antibiotic concentrations in sinus secretion and sinus mucosa to ensure therapeutic success was demonstrated. Thus, bacterial growth remained in the secretions of most maxillary sinuses when the concentrations of penicillin or tetracycline in the secretions were not regarded as adequate for treatment. In contrast, the bacteria were exterminated in most cases where concentrations were regarded as adequate.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=818872&dopt=Abstract
Antibiotiki. 1976 Apr;21(4):316-20.
[Increasing the threshold sensitivity of the spot detection reaction on a chromatogram]
[Article in Russian]
Serova LI, Korchagin VB, Kotova NI, Tomashchik AD.
A known analytical procedure was used for increasing the sensitivity threshold of the reaction of the zone opening on chromatogrammes. The procedure was the following: the carboxylic acid admixtures determined chromatographically were previously extracted from dry samples of the test-compounds into an optimal solvent. The expediency of the procedure was shown on examples of phenylacetic, phenoxyacetic and isoxasolcarboxylic acids present as admixtures in semisynthetic penicillins and raw materials used for their preparation. The threshold sensitivity was increased by 6 to 9 times. The chromatographic separation was performed in a fixed layer of Silica Gel KSK treated with a buffer. The mobile phase was used in the form of a solvent system: n-heptan-glacial acetic acid (95:5).
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=818950&dopt=Abstract
Med Klin. 1976 Jul 9;71:1197-9.
[Therapy and prophylaxis of recurrent erysipelas (author's transl)]
[Article in German]
Ziebart-Schroth A.
17 patients suffering from chronically recurrent erysipelas were treated through 10 days - every day - with 10 mega Na-penicillin G intravenously, before noon, and with 1.2 mega (900000 units clemizole penicillin G plus 300000 units Na-penicillin G) intramuscularly or 1 to 2 mega penicillin V acid orally, in the afternoon. Thereafter, these patients were to be injected through six months, in two week intervals, a repository penicillin (600000 units benzathine penicillin G, 300000 unmand in a divers manner. During the observation period from 1 7/12 to 2 8/12 years, 11 out of 17 patients remained without relapse. Frequency of recidivation significantly decreased in 3 patients; no improvement was achieved in the three last patients.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=822266&dopt=Abstract
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