Drugs online research references
Scand J Infect Dis. 1975;7(2):141-5.
Influence of diarrhea on the oral absorption of penicillin V and ampicillin in children.
Bolme P, Eriksson M.
Oral ampicillin and penicillin V was given to 23 and 42 children, respectively, with upper respiratory infections. The absorption of the drugs was followed on one of the first days of treatment for 3 hours after administration by taking capillary samples and determining the serum levels. Approximately 60% of the children were tested for oral absorption during convalescence, 6-8 days after the initiation of the treatment. Diarrhea was evident in more than 60% of the children during treatment with both ampicillin and penicillin V. Diarrhea of short duration did not have influence on the absorption of the antibiotics. Only when persistent diarrhea over the whole therapy period existed, absorption of penicillin V was decreased.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=809836&dopt=Abstract
Scand J Infect Dis. 1975;7(3):201-7.
Effect of consecutive antibacterial therapy on bacteriuria in hospitalized geriatric patients.
Alling B, Brandberg A, Seeberg S, Svanborg A.
The effects of treatment with a consecutive series of different antibacterial drugs, most of them commonly used in urinary tract infections, were studied in 36 hospitalized geriatric patients with bacteriuria. Most of the patients had advanced handicaps and all had urinary incontinence. Urinary acidifying drugs, penicillin V, sulfonamide, nitrofurantoin, nalidixic acid, and trimethoprim/sulfamethoxazole were used as antibacterial agents. The general conclusion was that even the administration of a series of potent antibacterial drugs only rather seldom eliminates bacteriuria in such patients, and that the original bacteria in most cases are replaced by strains highly resistant to antibacterial drugs. The treatment had obvious influence on the clinical state only in one patient.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=809837&dopt=Abstract
J Antibiot (Tokyo). 1975 Sep;28(9):668-75.
Chemical-ionization mass spectrometry of beta-lactam antibiotics.
Mitscher LA, Showalter HD, Shirahata K, Foltz RL.
Chemical-ionization (CI) mass spectra are described for methyl esters of eight clinically significant penicillins and their breakdown products. The substances give spectra with very few fragment ions and contain easily discernible protonated molecule ions. The main cleavage reaction is postulated to involve a retro 2+2 Diels-Alder-type fragmentation of the beta-lactam ring liberating one fragment (m/e=174) that is characteristic of the penicillin nucleus and a second fragment that is molecule specific, as it contains the elements of the side chain. The other fragment ions, though interesting, are of minor intensity. The free acids, on the other hand, fragment more extensively because of their relative instability and lack of volatility. These spectra resemble electron impact spectra more closely and, though they encode more structural information, are less reproducible from run to run. The ease with which the esters can be made and the relative simplicity of their CI mass spectra make this method significant for the identification and characterization of beta-lactam antibiotics.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=810468&dopt=Abstract
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