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Can J Comp Med. 1975 Apr;39(2):227-30.
Effect of penicillin on the humoral and cellular immune response following group A streptococcal pharyngitis.

Zimmerman RA, Klesius PH, Krushak DH, Mathews JH.

The effect of oral and parenteral penicillin on the development of cellular and humoral immune responses in chimpanzees infected with group A streptococcal M-types 1, 5 and 12 was investigated. The interrelationship between type-specific antibody response and enhancement of phagocytic competence of polymorphonuclear neutrophils was documented. Penicillin depressed or suppressed type-specific antibody response depending on the mode and dose of administration, probably because of its effect on the streptococci responsible for antibody stimulation. Penicillin was not demonstrated to have a direct effect on phagocytic ability in vitro. Therefore the primary effect of antibiotic therapy is the indirect relationship to suppression or inhibition of type-specific antibody response to M-protein which results in a diminution of phagocytic competence.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=804981&dopt=Abstract




J Hyg Epidemiol Microbiol Immunol. 1975;19(1):72-8.
Bioautographic characterization of antimicrobial substances after electrophoresis in agar gel.

Porres JM.

Bioautography following electrophoresis on agar gel, a technique for the characterization of antibiotics, is described in detail and its possible uses and advantages discussed. Eleven antibiotics of the beta-lactamic group were characterized. Penicillin G and Penicillin V showed two components with anti-microbial activity. Attempts were made to identify the components by an adaptation of the technique and the results are discussed.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=805172&dopt=Abstract




Bibl Cardiol. 1975;(33):191-4.
Ultrasonic-cardiographic long-term observations in patients with operated stenosis of the mitral valve.

Bellin H, Towe J.

135 patients operated for stenosis of the mitral valve were observed and treated 10.3 years, on the average. Three years of this time belong to the preoperative period and 7.3 years to the postoperative one. For evaluating the degree of stenosis, several ultrasound cardiograms were made yearly. After the operation one ultrasound examination was made every year for observing progress. In order to examine the effect of penicillin metaphylaxis on the process of restenosis, the patients were classified into different groups. The best operative result was maintained if continuous postoperative treatment with penicillin was made.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=805588&dopt=Abstract













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