Drugs online research references
Fortschr Med. 1982 Sep 9;100(34):1577-8.
[In vitro activity and resistance behavior of the penicillins against Staph. aureus]
[Article in German]
Gussmann S.
Strains of staphylococci sensitive and resistant to ampicillin were examined in their resistance to oxacillin, propicillin and penicillin G. For all the examined strains oxacillin showed values in the range of sensitiveness, propicillin proved itself distinctly more active in vitro than penicillin G resp. V. The satisfactory pharmacokinetic properties and the higher stability against penicillinase might result in an increased therapeutical security of the treatment with propicillin compared with penicillin V.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6813210&dopt=Abstract
J Int Med Res. 1982;10(5):379-82.
Bioavailability of paediatric mixtures containing phenoxymethylpenicillin calcium or potassium salt.
Soininen K, Allonen H, Posti J.
The bioavailability of the calcium and potassium salts of phenoxymethyl-penicillin (dose 38,000 I.U./kg) was investigated in eight healthy adult volunteers. Administration of the calcium salt as an aqueous oral mixture resulted in a mean peak plasma concentration of 8.52 mg/l (SD 1 X 96) and that of the potassium salt mixture in a concentration of 8.40 mg/ml (SD 2.61), p greater than 0.1. The median time-to-peak levels were 0.75 h and 1.0 h, respectively (p greater than 0.1). The mean AUC for the calcium salt mixture was 16.94 mg X h/l (SD 3.31) and for the potassium salt 15.84 mg X h/l (SD 4.76), p less than 0.09. These findings confirm that an aqueous mixture of calcium phenoxymethylpenicillin is equivalent to a mixture of potassium phenoxymethylpenicillin.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6814968&dopt=Abstract
Clin Pediatr (Phila). 1982 Nov;21(11):650-5.
Long-term follow-up of ambulatory management of osteomyelitis.
Dunkle LM, Brock N.
Over four years, 50 patients with osteomyelitis (32 classified as acute and 18 as subacute or chronic disease) were treated with oral antibiotics in an ambulatory setting. The profile of clinical and laboratory parameters, including etiologic agents, was similar to previous series. Forty-eight patients initially received parenteral drugs, mean duration 14 days (range 0-36). Oral agents administered at home included cephalosporins, clindamycin, dicloxacillin, penicillin VK, amoxicillin, and sulfa-trimethoprim. Mean duration of total therapy was 53.2 days (range 16-365). In follow-up, ranging from 12 to 60 months (mean 35), relapses occurred in one patient with acute and one with chronic disease. Both responded to oral treatment. No residual infection has resulted, although clinical and radiographic sequelae remain in six more patients initially termed subacute or chronic. Long-term follow-up of patients receiving high-dose oral antibiotic therapy for osteomyelitis due to sensitive organisms confirms the safety and efficacy of this mode of treatment and the feasibility of ambulatory management. The outcome after oral therapy is equivalent to that following parenteral therapy. Patients with subacute or chronic disease have a significantly poorer prognosis despite a milder initial illness and longer course of therapy.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7127987&dopt=Abstract
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