Drugs online research references
J Int Med Res. 1981;9(3):189-90.
Absorption of penicillin V from mixture formulations. Comparison of potassium and benzathine salts.
Heikinheimo M, Hovi T.
The absorption rate and serum level curves of two commercial phenoxymethylpenicillin mixture preparations were compared in adult volunteers. Both the potassium salt (Primcillin) and the benzathine salt (V-Pen ped forte) of V-penicillin were rapidly absorbed and the mean peak serum levels were obtained with both preparations within the first hour after single dose administration. The mean peak level obtained with the potassium salt was several-fold higher (p less than 0.001) and was also reached within a shorter time than that of the benzathine preparation. These results confirm the earlier evidence, obtained with other formulae, for the superior bioavailability of the potassium salt of V-penicillin as compared to most other derivatives used in V-penicillin mixtures.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6786935&dopt=Abstract
J Antibiot (Tokyo). 1980 Nov;33(11):1348-51.
Association of 6-oxo-piperidine-2-carboxylic acid with penicillin V. Production on Penicillium chrysogenum fermentations.
Brundidge SP, Gaeta FC, Hook DJ, Sapino C Jr, Elander RP, Morin RB.
Analysis of a 13C NMR spectrum of a concentrated broth from Penicillium chrysogenum fermentation revealed the presence of penicillin V and 6-oxo-piperidine-2-carboxylic acid(1) as the principal constituents. The latter lactam, identical to an authentic sample prepared by the cyclization of alpha-aminoadipic acid was present to the extent of 28 mol% of penicillin V. The lactam isolated form the broth was nearly racemic, having a slight excess of the L-isomer. This isolation provides further evidence regarding the biosynthetic precursors of the hydrophobic penicillins.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6788737&dopt=Abstract
Scand J Infect Dis. 1978;10(3):223-7.
Absorption of phenoxymethylpenicillin in children. The influence of age, state of disease and pharmaceutical preparation.
Bolme P, Eriksson M.
The bioavailability of phenoxymethylpenicillin (pc V) was determined in children with upper respiratory infection (age 1 month-5 years) following the administration of different commercial preparations of pc V. Administration of potassium pc V in water solution resulted in a significantly higher plasma concentration than the same dose of potassium pc V in an oil vehicle. There was no difference in absorption between tablet and mixture (the water solution) when potassium pc V was given, but with calcium pc V lower plasma levels were found after the oil mixture form than after the tablets. The results indicate that the oil mixture form and not the type of salt is responsible for the decreased absorption observed after some preparations of pc V. The absorption of solutions of potassium and calcium pc V was also examined in two different age groups, 1--5 months and 6 months-5 years. For both preparations the younger children obtained higher plasma levels. In 4 children with coeliac disease a decreased absorption compared to control children was found of potassium pc V in solution and this was most pronounced when the oil vehicle was used.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=102021&dopt=Abstract
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