Drugs online research references
Scand J Infect Dis Suppl. 1980;Suppl 24:204-9.
Effects of phenoxymethylpenicillin, clindamycin and tinidazole on the anaerobic oral, throat and colon flora in man.
Heimdahl A, Lindqvist L, Nord CE.
Capsules of phenoxymethylpenicillin were given orally to ten subjects in doses of 800 mg twice daily for 7 days. Saliva, throat and faecal specimens were taken over a 29-day period and bacterial cultivations were carried out. No changes in the normal flora of the saliva, throat or faeces were noted during this period. Clindamycin was given orally to ten other subjects in doses of 150 mg, four times per day for 7 days. No changes in the aerobic flora of the saliva and throat were observed while a significant decrease in the number of anaerobic bacteria occurred. Overgrowth of clostridia was seen in two cases. Pronounced changes in the faecal flora occurred. Among the aerobic bacteria, enterococci proliferated, and among the anaerobic bacteria significant decreases in the numbers of cocci and gram-negative rods were seen. In four subjects the number of clostridia increased significantly. Tinidazole was given orally to ten other subjects in doses of 150 mg every 12 hours for 7 days. Slight changes were noted in the anaerobic flora of the saliva while no differences were seen for the faecal flora.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6782660&dopt=Abstract
Rev Infect Dis. 1981 Jan-Feb;3(1):121-4.
Levels of antibiotic in human blood and interstitial fluid after oral administration of bacampicillin or phenoxymethyl penicillin and intravenous administration of amoxicillin or ampicillin.
Tan JS, Salstrom SJ, File TM Jr.
Levels of antibiotic in the serum and interstitial fluid were determined for 11 volunteers who received conventional doses of either phenoxymethyl penicillin (penicillin V) or bacampicillin orally and for 11 volunteers who received either amoxicillin or ampicillin intravenously. The levels of antibiotic achieved in both blood and interstitial fluid were higher in the volunteers who received bacampicillin than in those who received penicillin V. The levels of antibiotic in serum and interstitial fluid of participants in the study who received amoxicillin or ampicillin intravenously were comparable with those achieved with equivalent doses of oral bacampicillin. The lowest levels of antibiotic in serum and interstitial fluid were obtained in volunteers who received oral penicillin V, whereas the highest levels were obtained in those given ampicillin and amoxicillin intravenously.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6784223&dopt=Abstract
Clin Allergy. 1981 Mar;11(2):155-60.
Diagnosis of penicillin allergy by means of Phadebas RAST penicilloyl G and V and skin tests.
Jarisch R, Roth A, Boltz A, Sandor I.
Fifty patients with suspected allergy to penicillin were tested. Skin tests were done with Na-penicillin G and penicilloyl-polylysin. Specific IgE antibody assays were done with penicilloyl G and V conjugates by means of RAST. The overall agreement between skin test and RAST results was 87%, borderline cases not included. In one case, skin tests were positive to penicillamine only, while RAST for penicilloyl G and V both proved to be positive. One case of penicillin allergy could be diagnosed in vitro post mortem only. Two cases of Hoigne syndrome showed no evidence of allergy. Patterns of skin manifestations varied but urticaria was the most commonly seen feature. Twenty patients without adverse reactions to penicillin treatment and seven patients who had not received penicillin over the last 10 years served as controls. None of them were positive in either skin tests of RAST. Two or our twenty control patients developed penicillin allergy during the study. Both showed positive RAST results.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6786795&dopt=Abstract
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