Drugs online research references
J Periodontol. 1980 Jan;51(1):44-8.
The use of prophylactic penicillin in periodontal surgery.
Pendrill K, Reddy J.
In an attempt to prevent postoperative sequellae dentists often prescribe penicillin or other antibiotics following periodontal surgery. A review of the literature shows conflicting reports about this procedure. This study investigated the efficacy of prophylactic penicillin in 19 human subjects undergoing periodontal surgery. Following initial therapy, flap surgery was undertaken in at least two comparable quadrants in each patient. Using a split mouth technique, patients were either given phenoxymethyl penicillin or a placebo following flap surgery for 5 days. Pain, infection, plaque levels, gingivitis and crevicular fluid flow were measured during a 4 week period. There were no differences between the placebo or penicillin sides in any of the parameters studied, except that the pain experience was significantly lower on the penicillin operated side. Within the limitations of this study it is difficult to substantiate the routine use of antibiotics following periodontal surgery.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6767012&dopt=Abstract
Zh Mikrobiol Epidemiol Immunobiol. 1980 Jul;(7):25-9.
[Effect of antibiotics and bifiodobacterium preparations on the intestinal microflora of mice irradiated with gamma quanta]
[Article in Russian]
Korshunov VM, Pinegin BV, Mal'tsev VN, Kissina EV, Ikonnikova TB.
The treatment of CBA mice, irradiated in a dose of 700 Gy with antibiotics (penicillin V, oxytetracycline, streptomycin) in combination with bacterial therapy (B. bifidum, strain 75-41) or with antibiotics alone led to the increased percentage of survivors among them in comparison with the control animals. At the same time the medical prognosis was better in cases of the combined treatment with antibiotics and bifidobacteria. This circumstance was due to the fact that the combined treatment with antibiotics and bifidobacteria, considerably facilitated the normalization of the microbial picture of the intestine; in this case the "eubiosis" of the intestinal tract was almost completely restored by the 22nd day after the irradiation, whereas in the treatment with antibiotics alone the inhibitory effect on the development of the opportunistic flora at a later period of the development of dysbacteriosis was less pronounced, while the number of lactic acid bacteria remained at the same low level as in the untreated mice.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6776721&dopt=Abstract
prodigy.net
BACKGROUND: Up to 10% of the population reports an allergy to penicillin, yet more than 80% of these individuals lack penicillin-specific IgE antibodies. A negative result on a penicillin skin test is highly accurate in identifying who can safely receive the antibiotic at the time of testing. However, its negative predictive value for future courses is unknown because it is uncertain whether patients with a history of penicillin allergy are at risk of becoming resensitized. OBJECTIVE: To determine the rate of penicillin resensitization in adult patients with a history of penicillin allergy after they are challenged with repeated courses of oral penicillin. METHODS: Adult patients with a history of penicillin allergy consistent with an IgE-mediated mechanism were recruited and underwent penicillin skin testing. Those with negative skin test results were challenged with 3 successive 10-day courses of penicillin V potassium (250 mg by mouth 3 times a day), providing their penicillin skin test results remained negative prior to each course. Patients with positive skin test results were not challenged. RESULTS: Of 53 patients with initially negative skin test results, 46 completed the protocol, and each tolerated all 3 courses of penicillin with negative skin test results throughout. No patients had a converted skin test result from negative to a positive, yielding a resensitization rate of 0% (upper 95% confidence interval, 2.1%). CONCLUSIONS: Adult patients with a history of penicillin allergy are not at increased risk of resensitization after receiving 3 courses of oral penicillin. Because a negative penicillin skin test result is predictive for subsequent oral administrations beyond the time of testing, adult patients with a history of penicillin allergy can be skin tested electively, which may avoid unnecessary treatment with alternate broad-spectrum antibiotics.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11926858&dopt=Abstract
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