Drugs online research references
Minerva Psichiatr. 1996 Jun;37(2):91-7.
[Efficacy and tolerability of paroxetine in the treatment of the depressive phase of bipolar disorders]
[Article in Italian]
Ambrosio LA, Buccomino D, Filippo A, Morelli A, Musacchio R, Pupo F, Romano FE, Marchese G, Barrese E.
Divisione di Psichiatria, Ospedali Riuniti, Cosenza.
Eighty patients aged between 20-65 years and suffering from bipolar disease according to DSM IV criteria, were treated with paroxetine for os at the single dosage of 20-40 mg/die. At regular intervals psychometric reagents were administered for the evaluation and the variations in the bipolar disease. Tolerability was excellent and side-effects mild, with a tendency to regress after the second week of therapy. The clinical assessment and the psychometric findings both suggest that paroxetina has a useful action on the bipolar disease.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8926862&dopt=Abstract
note: kwd match paxil online literature
Ned Tijdschr Geneeskd. 1996 Sep 7;140(36):1817-20.
[Reports of suspected side effects of selective serotonin reuptake inhibitors in Belgium and The Netherlands]
[Article in Dutch]
Van Ermen AM, Ottervanger JP, Roisin T, Kurz X, Stricker BH.
Ministerie van Sociale Zaken, Volksgezondheid en Leefmilieu, Belgisch Centrum voor Geneesmiddelenbewaking, Brussel.
OBJECTIVE: To study the adverse drug reaction (ADR) profile of selective serotonin re-uptake inhibitors (SSRI) in Belgium and the Netherlands. DESIGN: Descriptive study. SETTING: The Belgian Pharmacovigilance Centre and the Dutch Drug Safety Unit. METHOD: All adverse reactions of fluoxetine, fluvoxamine, paroxetine and sertraline, reported between the moment of registration of these drugs and January 1st 1995, were assessed for causality. Possible, probable and certain adverse reactions were counted per drug and per country. RESULTS: At the national monitoring centres of Belgium and of the Netherlands adverse reactions were reported 78 and 537 times, respectively. Approximately 30% of the adverse reactions were well-established. Approximately 60% of the reactions were poorly documented or not serious. Less than 1% of the adverse reactions reported in Belgium and approximately 13% of the reactions reported in the Netherlands, were less established and/or serious. These reactions were: movement disorders and extrapyramidal reactions, convulsions, galactorrhoea, hyponatraemia and syndrome of inappropriate antidiuretic hormone secretion, and purpura. CONCLUSION: The ADR profile was compatible with the ADR profile in the medical literature, but not all ADR were similarly represented in the product information of the different SSRI. More adverse reactions were reported in the Netherlands than in Belgium.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8927144&dopt=Abstract
note: kwd match paxil online literature
Psychiatry Res. 1996 Jan 31;59(3):189-96.
Paroxetine shifts imipramine metabolism.
Albers LJ, Reist C, Helmeste D, Vu R, Tang SW.
Psychiatry Service, Long Beach Veterans Affairs Medical Center, CA 90822, USA.
The combination of selective serotonin reuptake inhibitors with tricyclic antidepressants has proven useful in treatment-resistant depression but has the potential for adverse drug-drug interactions. In the present study, the metabolism of a single dose of imipramine was studied before and after treatment with paroxetine. Paroxetine induced significant elevations of approximately 50% in half-life, area under the curve, and Cmax of imipramine and decreased clearance twofold. The effects on desipramine pharmacokinetics were even more pronounced. These findings indicate a significant interaction of paroxetine with the CYP2D6 isoenzyme.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8930024&dopt=Abstract
note: kwd match paxil online literature
Herbs and Pharmaceuticals Online ||
Hair Million herbal formula for hair loss and hair growth ||
Antibiotics and prescription medications online literature ||