Drugs online research references
Depress Anxiety. 2000;11(3):126-30.
Effects of nortriptyline and paroxetine on QT variability in patients with panic disorder.
Yeragani VK, Pohl R, Jampala VC, Balon R, Ramesh C, Srinivasan K.
Department of Psychiatry, Wayne State University School of Medicine, Detroit, Michigan, USA.
This study investigated beat-to-beat QT variability in patients with panic disorder before and after treatment with nortriptyline (n = 13) and paroxetine (n = 16), using an automated algorithm to compute QT intervals. An increase in QT variability appears to be associated with symptomatic patients with dilated cardiomyopathy and also with an increased risk for sudden cardiac death. QTvi (QT variability index: a log ratio of QT variance normalized for mean QT over heart rate variability normalized for mean heart rate) was significantly higher in supine posture in patients with panic disorder treated with nortriptyline (P = 0.006) but not paroxetine. Thus paroxetine may be a better drug of choice especially in patients with coexisting cardiac disease. These findings are important especially in view of the recent reports of increased risk for cardiovascular mortality and sudden death in patients with anxiety and depression. QTvi can be a valuable noninvasive measure of temporal repolarization lability, especially to study the side effects of medications which affect cardiac autonomic function.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10875054&dopt=Abstract
Gen Hosp Psychiatry. 2000 Jul-Aug;22(4):242-50.
Factors associated with symptomatic improvement and recovery from major depression in primary care patients.
Brown C, Schulberg HC, Prigerson HG.
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.
This article describes a post-hoc analysis of clinical and psychosocial factors and beliefs about health associated with treatment outcome in a sample of depressed primary care patients (N=181) randomly assigned to a standardized treatment or physician's usual care (UC). Different factors were found to predict clinical outcomes for treatment modality [UC vs. interpersonal psychotherapy (IPT) or nortriptyline (NT)] and the type of outcome evaluated (i.e., depressive symptoms at 8 months or symptomatic and functional recovery at 8 months). Factors associated with treatment-specific outcomes are also described. Consistent with prior studies, lower depressive symptom severity at 8 months was associated with higher baseline functioning, minimal medical co-morbidity, race, and standardized pharmacologic or psychotherapeutic treatment. Additionally, an interaction between treatment modality and health locus of control indicated that individuals perceiving more self-control of their health and who received a standardized treatment experienced greater depressive symptom reduction at 8 months. Factors associated with symptomatic and functional recovery from the depressive episode were also examined. Patients who received a standardized treatment (IPT or NT) perceived greater control of their health and lacked a lifetime generalized anxiety disorder or panic disorder were more likely to recover by month 8 than those who received usual care. While clinical severity and treatment adequacy play an important role in both symptomatic improvement and full recovery from a depressive episode, other key factors such as health beliefs and non-depressive psychopathology also influence recovery.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10936631&dopt=Abstract
Ther Drug Monit. 2000 Aug;22(4):427-31.
Time-dependent absorption of therapeutic drugs by the gel of the Greiner Vacuette blood collection tube.
Dasgupta A, Yared MA, Wells A.
Department of Pathology and Laboratory Medicine, University of Texas-Houston Medical School, 77030, USA.
Stability of therapeutic drugs in sera collected in Becton-Dickinson VACUTAINER serum separator SST tubes has been well studied. Recently, the Greiner Vacuette serum separator tube has become available for blood collection. However, stability of therapeutic drugs in sera when the specimen is collected in the Greiner tube has not been reported. The authors studied the stability of 15 commonly monitored drugs in sera when stored on the gel of the Greiner serum separator tubes. The drugs studied were amikacin, gentamycin, tobramycin, vancomycin, digoxin, quinidine, theophylline, carbamazepine, phenobarbital, phenytoin, valproic acid, tricyclic antidepressants, salicylate, acetaminophen, and ethanol. The authors compared the concentrations of drugs in sera stored in plain tubes (no gel) and in sera stored in the Greiner tubes containing serum separator gel. They observed a significant decline in the concentrations of tricyclic antidepressants when stored in the Greiner tubes. Interestingly, concentrations of amitriptyline declined more than its metabolite nortriptyline and concentration of imipramine also decreased more than its metabolite desipramine. The concentration of carbamazepine also decreased slightly over time when serum was stored in the Greiner tube. Although declines in carbamazepine concentrations on prolonged storage in the Greiner tubes were statistically significant, the decreases may not be clinically significant. The concentrations of the other drugs studied did not decline when stored in the Greiner tubes. The authors conclude that the Greiner brand tube is not suitable for blood collection for analysis of tricyclic antidepressants.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10942183&dopt=Abstract
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