Drugs online research references
Clin Chem. 1982 Oct;28(10):2143-8.
Liquid-chromatographic determination of amitryptyline and its metabolites in serum, with adsorption onto glass minimized.
Edelbroek PM, de Haas EJ, de Wolff FA.
To study correlations between the concentrations, in serum, of amitriptyline and its most important metabolites with clinical response in patients, we developed a "high-performance" liquid-chromatographic method for routine determination of amitriptyline, nortriptyline, total 10-hydroxy-amitriptyline, desmethylnortriptyline, and E(trans)- and Z(cis)-10-hydroxynortriptyline. These compounds are extracted from 1 mL of alkalinized serum into hexane/isoamyl alcohol (99/1 by vol). Perazine is the internal standard. To minimize irreversible adsorption of the drugs onto the glassware, 5 micrograms of maprotiline is added to the organic phase just before evaporation. After a 10-min resolution on a silica column eluted with acetonitrile/methanol/NH4OH (1 mol/L), absorbance is measured at 240 nm. Only chlorimipramine, doxepin, procainamide, and N-acetylprocainamide may interfere with assay of the compounds that probably are therapeutically relevant: amitriptyline, nortriptyline, and E-10-hydroxynortriptyline. Uremia, lipemia, and icterus also do not affect the analysis.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7127744&dopt=Abstract
J Clin Psychopharmacol. 1987 Apr;7(2):67-71.
Initial severity and diagnosis influence the relationship of tricyclic plasma levels to response: a statistical review.
Boyer WF, Lake CR.
There is considerable controversy about the clinical value of monitoring tricyclic antidepressant plasma levels. To investigate this issue the authors pooled data from 17 published plasma level studies of imipramine, amitriptyline, or nortriptyline, involving over 400 patients. The findings suggest that tricyclic antidepressant plasma level monitoring is important primarily for patients who are severely depressed or who have endogenous features. Monitoring is especially important for such patients who are treated with amitriptyline or nortriptyline, since failure to respond may be associated with very low or very high plasma levels. These data have implications for tricyclic antidepressant plasma level monitoring and future research.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3584523&dopt=Abstract
Br J Pharmacol. 1980 Jun;69(2):163-6.
Involvement of a central alpha-adrenoceptor system in antidepressant potentiation of hyperthermia induced by thyrotropin releasing hormone.
Desiles M, Puech AJ, Rips R.
Thyrotropin releasing hormone (TRH) causes hyperthermia in mice which is potentiated by tricyclic antidepressants (nortriptyline, imipramine, clomipramine, amitriptyline), the monoamine oxidase inhibitor, tranylcypromine, and various other antidepressants (maprotiline, nomifensin, viloxazine). Only iprindole is ineffective. The effect of mianserin, itself hypothermic, could not be interpreted. A property shared by the potentiating substances seems to be activation of a central adrenoceptor system. The potentiation of TRH-induced hyperthermia which seems to be specific to antidepressants might be used in the selection of antidepressants.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6254586&dopt=Abstract
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