Drugs online research references
Prog Neuropsychopharmacol. 1979;3(4):369-76.
Metabolic interaction between amitriptyline and perphenazine in psychiatric patients.
Cooper SF, Dugal R, Elie R, Albert JM.
Centre de recherches en sciences de la sante, Institut National de la Recherche Scientifique, Montreal.
1. Steady-state plasma level samples of sixty-five schizophrenic patients from two psychiatric hospitals assigned to three treatment groups (amitriptyline 150 mg/day, perphenazine 20 mg/day and a combination of amitriptyline and perphenazine at 150 mg and 20 mg/day) were assayed for amitriptyline (AT), endogenous nortriptyline (NT) and perphenazine (PPZ) using gas-liquid chromatography. 2. Results reveal that AT and NT levels are independent of sex and hospital environment. 3. PPZ significantly increased the steady-state NT plasma levels, probably through inhibition of the hydroxylation biotransformation pathway, but had no effect on AT levels, thus indicating that PPZ has no influence on the desmethylation pathway, or alternatively, the hydroxylation of AT.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=400992&dopt=Abstract
J Clin Psychopharmacol. 1982 Feb;2(1):8-13.
EEG sleep and tricyclic blood levels: acute and chronic administration in depression.
Kupfer DJ, Hanin I, Coble PA, Spiker DG, Sorisio D, Grau TG.
An understanding of the effects of antidepressants on sleep can be aided by determinations of tricyclic plasma levels in relationship to sleep. Previous studies have been established that steady state plasma levels of amitriptyline relate to certain aspects of rapid eye movement (REM) sleep. The present investigations attempt to replicate the REM sleep/tricyclic plasma level relationships in a larger group of psychiatric hospitalized patients for depression and to study whether such relationships persist in a group of ambulatory patients studied longitudinally for 1 to 2 years. In an acute treatment study of 38 patients, REM sleep percent and average REM activity demonstrated a significant relationship with plasma levels, even when controlled for age and severity. The sleep-plasma level relationships seem more prominent with amitriptyline levels than with nortriptyline plasma levels. In a long term comparison of plasma levels, tricyclic plasma levels showed a significant correlation with REM latency, REM percent and average REM activity. Thus, it appears that changes in REM sleep such as REM suppression correlate significantly with tricyclic plasma levels both on a short (4 weeks) and long term basis (1 to 2 years). The implications of these findings are discussed.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7068946&dopt=Abstract
Psychopathology. 1986;19 Suppl 2:79-84.
New aspects in research on blood levels and bioavailability of antidepressants.
Baumann P.
Recent research has been oriented towards the study of the clinical relevance of measuring free and total plasma levels of antidepressants and their hydroxylated metabolites, as animal experiments suggest that the latter may be clinically active. In central Europe, about 5-10% of the population has a genetic defect in metabolizing debrisoquine. This is of importance for pharmacopsychiatry, as some antidepressants like desipramine, nortriptyline, amitriptyline, imipramine (and possibly maprotiline) are metabolized by the same enzyme as debrisoquine. This observation helps to understand not only the large interindividual differences in the steady-state levels of these drugs but also drug interferences.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3575631&dopt=Abstract
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