Drugs online research references
J Anal Toxicol. 1990 Jul-Aug;14(4):217-8.
Percutaneous absorption of tricyclic antidepressants: amitriptyline, nortriptyline, imipramine, and desipramine.
Bailey DN.
Department of Pathology, University of California Medical Center, San Diego 92103.
The percutaneous absorption of amitriptyline, nortriptyline, imipramine, and desipramine as their hydrochloride salts in vivo was demonstrated without use of a vehicle using the hairless (hr-1/hr-1) mouse as an experimental model for human skin. After topical application of 2 mg of each compound in distilled water, followed by rapid evaporation of the water, concentrations were measured in heart, lung, brain, liver, and blood in 1-, 2-, 4-, and 6-hour study groups. Lung consistently demonstrated the highest concentrations for all four compounds while heart and liver had the lowest. Concentrations in heart remained essentially constant for all compounds during the 6-hour study period. The concentrations in solid tissues were much lower than those commonly seen in man after overdose, whereas the concentrations in blood resembled low therapeutic to toxic concentrations in humans. Percutaneous absorption may provide a feasible route of administration for the tricyclic antidepressants which may lead to improved compliance with fewer gastrointestinal side effects.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2395341&dopt=Abstract
Ther Drug Monit. 1984;6(4):444-8.
Blood collection tubes for tricyclic antidepressant drugs: a reevaluation.
Orsulak PJ, Sink M, Weed J.
We tested clinical samples from patients receiving four commonly monitored antidepressant drugs--amitriptyline, nortriptyline, imipramine, and desipramine--to evaluate the reliability of currently available Becton-Dickinson Vacutainer brand vacuum blood collection tubes. Serum tubes (red stopper), heparinized plasma tubes (green stopper), and two types of serum separator tubes (SST) were evaluated. Antidepressant concentrations were measured by reversed-phase high-performance liquid chromatography. Antidepressant levels obtained using fresh serum (red stopper) or plasma (green stopper) yielded equivalent results. Serum collected in red-stopper tubes was stored at 4 degrees C for 4 weeks without detectable loss of antidepressant drugs. Significant concentration decreases for amitriptyline, imipramine, and desipramine were noted when serum was collected in SST tubes to such an extent that SST tubes cannot be used for the procedure. Bias attributed to SST tubes can interfere with the usefulness of clinical results over the entire therapeutic ranges of these drugs.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6515704&dopt=Abstract
Eur J Pharmacol. 1980 Mar 21;62(2-3):147-55.
Inhibition of (3H)-dopamine uptake into rat brain synaptosomes by the new non-tricyclic antidepressants, FS32 and FS97.
Koide T, Uyemura K.
The effects of new non-tricyclic antidepressants, FS32 and its desmethylated compound (FS97), on the uptake of (3H)-dopamine (DA) by rat purified whole brain synaptosomes and the striatal synaptosomes were studied. The uptake into synaptosomes was time- and temperature-dependent and was saturable with a Km value of 9.1 X 10(-8) M. The inhibiting activities of both compounds were comparable to those of amitriptyline, nortriptyline and iprindole, and were nearly twice the activity of imipramine and desipramine. The kinetic constants indicated that both FS32 and FS97 were competitive inhibitors of (3H)-DA uptake. Neither drug caused a significant release of (3H)-DA from the synaptosomes.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7379837&dopt=Abstract
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