Drugs online research references
Ther Drug Monit. 1988;10(2):164-7.
Isomers of 10-hydroxynortriptyline in geriatric depression.
Young RC, Dhar AK, Kutt H, Alexopoulos GS.
Department of Psychiatry, New York Hospital-Cornell Medical Center, White Plains 10605.
In geriatric, depressed inpatients treated with nortriptyline (NT), total unconjugated plasma concentrations of the Z isomer of the 10-hydroxylated metabolite (10-OH-NT) were determined simultaneously with concentrations of the E isomer by high-performance liquid chromatography. Z-10-OH-NT concentrations averaged 14% of E-10-OH-NT concentrations.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3381232&dopt=Abstract
J Psychiatry Neurosci. 1995 Jan;20(1):25-32.
Acute treatment with antidepressant drugs selectively increases the expression of c-fos in the rat brain.
Beck CH.
Department of Psychology, University of Alberta, Edmonton, Canada.
Rats were treated acutely, ip, with saline vehicle or an antidepressant: iprindole (15 mg/kg), nortriptyline (15 mg/kg), A75200 (10 mg/kg), fluoxetine (15 mg/kg), desipramine (10 mg/kg), bupropion (20 mg/kg) or tranylcypromine (7.5 mg/kg). Mapping the neuroanatomical distribution at 64 sites of the immediate early gene, c-fos revealed several patterns: first, increased counts of Fos-like neurons were found in all but one instance; second, drugs which had dopaminergic effects (bupropion and tranylcypromine) were more likely to potentiate c-fos reactivity than were the other drugs; third, Fos-like counts were more likely to be significantly elevated in structures bordering brain ventricles; fourth, only in the central amygdala were the Fos-like counts higher in all seven drug groups relative to the saline group. It remains to be seen whether or not this shared substrate is therapeutically significant.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7865498&dopt=Abstract
J Chromatogr. 1977 Sep 1;143(5):491-7.
Quantitative analysis of tricyclic antidepressants in serum from psychiatric patients.
Nyberg G, Martensson E.
A method for the quantitative analysis of tricyclic antidepressants in the serum of psychiatric patients is described. The method can be used for determining amitriptyline, nortriptyline, imipramine, demethyllimipramine, clomipramine, demethylclomipramine, trimipramine and protriptyline. The method consists in a series of extraction steps followed by gas chromatography with flame-ionization detector. The drugs are determined in their native state. The internal standard method is used for the quantitation.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=561116&dopt=Abstract
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