Drugs online research references
Neuropsychobiology. 1980;6(1):52-5.
Plasma prolactin during treatment with nortriptyline.
Nielsen JL.
The plasma concentrations of prolactin and nortriptyline were determined in 17 patients with endogenous depression treated for 4 weeks with nortriptyline once a day. None of the patients developed galactorrhoea. A moderate but statistically significant increase (about 25%) in the plasma prolactin was found after 3 weeks of treatment. There was no correlation between the plasma levels of prolactin and of nortriptyline. The results indicate that nortriptyline does not belong to the group of psychotropics which produce considerable increases in the plasma concentration of prolactin.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7366815&dopt=Abstract
Psychiatr J Univ Ott. 1989 Sep;14(3):460-2.
Therapeutic monitoring of treatment with antidepressants.
Bourin MS, Kergueris MF, Lapierre YD.
The present status of the relationship between blood plasma concentrations of tricyclic antidepressants and clinical outcome is reviewed. Plasma levels of imipramine, desmethylimipramine and nortriptyline are generally accepted as useful clinically but it is more difficult to establish a well-defined relationship between clomipramine and amitriptyline blood levels and clinical outcome. These assays are clinically relevant, particularly in cases of treatment failure, but also in the treatment of the elderly and of overdosage. The technical problems of the assay have practically been solved with the development of new analytic methods.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2678187&dopt=Abstract
J Anal Toxicol. 1990 May-Jun;14(3):168-71.
Use of the EMITtox serum tricyclic antidepressant assay for the analysis of urine samples.
Asselin WM, Leslie JM.
Royal Canadian Mounted Police, Forensic Laboratory, Vancouver, British Columbia, Canada.
The EMITtox serum tricyclic antidepressant (TCA) assay is intended for use with serum or plasma. Currently, there are no commercially available immunoassay kits available for the detection of TCAs in urine. The proposed method utilizes the EMITtox serum TCA assay for the direct analysis of urine samples. The minimum detectable concentration of nortriptyline in urine is 25 ng/mL. The within-run CV was determined to be 0.6% and the between-run CV was 2.6%. The TCA assay cross-reacts with phenothiazines and antihistamines. The proposed methodology should be applicable to other EMIT serum assays to allow their use with urine.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1973748&dopt=Abstract
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